Prognostic Value of Desaturation during a 6 Minute Walk Test in Idiopathic Interstitial Pneumonia

Vibha N. Lama, Kevin R. Flaherty, Galen B. Toews, Thomas V. Colby, William D. Travis, Qi Long, Susan Murray, Ella A. Kazerooni, Barry H. Gross, Joseph P. Lynch, Fernando J. Martinez

Research output: Contribution to journalArticlepeer-review

375 Scopus citations

Abstract

Exercise-induced hypoxia is an index of the severity of interstitial lung disease. We hypothesized that desaturation during a 6-minute walk test would predict mortality for patients with usual interstitial pneumonia (n = 83) and nonspecific interstitial pneumonia (n = 22). Consecutive patients with biopsy-proven disease performed a 6-minute walk test between January 1996 and December 2001. Desaturation was defined as a fall in oxygen saturation to 88% or less during the 6-minute walk test. Desaturation was common (44 of 83 usual interstitial pneumonia and 8 of 22 nonspecific interstitial pneumonia; chi square, p = 0.39). Patients with usual interstitial pneumonia or nonspecific interstitial pneumonia who desaturated had a significantly higher mortality than patients who did not desaturate (respective log-rank tests, p = 0.0018, p = 0.0089). In patients with usual interstitial pneumonia, the presence of desaturation was associated with an increased hazard of death (hazard ratio, 4.2; 95% confidence interval, 1.40, 12.56; p = 0.01) after adjusting for age, sex, smoking, baseline diffusion capacity for carbon monoxide, FVC, and resting saturation. We conclude that knowledge of desaturation during a 6-minute walk test adds prognostic information for patients with usual interstitial pneumonia and nonspecific interstitial pneumonia.

Original languageEnglish (US)
Pages (from-to)1084-1090
Number of pages7
JournalAmerican journal of respiratory and critical care medicine
Volume168
Issue number9
DOIs
StatePublished - Nov 1 2003

Keywords

  • 6-minute walk test
  • Nonspecific interstitial pneumonia
  • Usual interstitial pneumonia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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