Prognostic value of bone marrow angiogenesis in patients with multiple myeloma undergoing high-dose therapy

S. Kumar, M. A. Gertz, A. Dispenzieri, M. Q. Lacy, L. A. Wellik, R. Fonseca, J. A. Lust, T. E. Witzig, R. A. Kyle, P. R. Greipp, S. Vincent Rajkumar

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Bone marrow (BM) angiogenesis is increased in multiple myeloma and is an important prognostic factor. However, prior studies were mainly done on patients receiving conventional chemotherapy and there is limited data on its prognostic value in patients undergoing high-dose therapy (HDT) as initial therapy. We studied BM angiogenesis in terms of microvessel density (MVD) in 88 newly diagnosed patients, who were uniformly treated, with 3-4 cycles of induction chemotherapy followed by HDT. We examined if MVD at diagnosis was predictive of response to induction therapy or to subsequent HDT. In addition, we also examined its prognostic value in these patients. The median MVD for primary refractory patients was 28 (range, 2-84) compared to 27 (range, 2-99) for responding patients (P = 0.7). The median progression-free survival (PFS) was 21 months for those with high-grade angiogenesis compared to 42 months for those with low-grade angiogenesis, P = 0.017. The median overall-survival (OS) from diagnosis was 40 months for those with high-grade angiogenesis and not yet reached, for those with low-grade angiogenesis, P = 0.007. BM MVD at the time of initial diagnosis is an important prognostic factor for OS and PFS in patients undergoing autologous transplantation as frontline therapy for myeloma.

Original languageEnglish (US)
Pages (from-to)235-239
Number of pages5
JournalBone Marrow Transplantation
Volume34
Issue number3
DOIs
StatePublished - Aug 1 2004

Keywords

  • Angiogenesis
  • Multiple myeloma
  • Prognosis
  • Refractory
  • Stem cell transplantation

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Fingerprint Dive into the research topics of 'Prognostic value of bone marrow angiogenesis in patients with multiple myeloma undergoing high-dose therapy'. Together they form a unique fingerprint.

  • Cite this