Prognostic value of angiogenesis in solitary bone plasmacytoma

Shaji K Kumar, Rafael Fonseca, Angela Dispenzieri, Martha Lacy, John A. Lust, Linda Wellik, Thomas Elmer Witzig, Morie Gertz, Robert A. Kyle, Philip R. Greipp, S Vincent Rajkumar

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Angiogenesis plays an important role in the biology of multiple myeloma (MM) and has prognostic importance in this disease. Solitary plasmacytoma is a localized plasma cell malignancy that progresses to MM in a significant number of patients. We examined if angiogenesis is increased in solitary plasmacytoma and if it can help identify patients likely to progress to myeloma. We studied angiogenesis in plasmacytoma biopsy samples and bone marrow biopsies from 25 patients. High-grade angiogenesis was present in 64% of plasmacytomas. In contrast, bone marrow angiogenesis was low in all patients. Patients with high-grade angiogenesis in the plasmacytoma sample were more likely to progress to myeloma and had a shorter progression-free survival compared with patients with low-grade angiogenesis (P = .02). Angiogenesis is increased in solitary plasmacytoma and is a significant predictor of progression to myeloma and provides further evidence of its importance in the pathogenesis of myeloma.

Original languageEnglish (US)
Pages (from-to)1715-1717
Number of pages3
JournalBlood
Volume101
Issue number5
DOIs
StatePublished - Mar 1 2003

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Plasmacytoma
Biopsy
Bone
Bone and Bones
Multiple Myeloma
Plasmas
Bone Marrow
Plasma Cells
Disease-Free Survival
Neoplasms

ASJC Scopus subject areas

  • Hematology

Cite this

Prognostic value of angiogenesis in solitary bone plasmacytoma. / Kumar, Shaji K; Fonseca, Rafael; Dispenzieri, Angela; Lacy, Martha; Lust, John A.; Wellik, Linda; Witzig, Thomas Elmer; Gertz, Morie; Kyle, Robert A.; Greipp, Philip R.; Rajkumar, S Vincent.

In: Blood, Vol. 101, No. 5, 01.03.2003, p. 1715-1717.

Research output: Contribution to journalArticle

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AU - Fonseca, Rafael

AU - Dispenzieri, Angela

AU - Lacy, Martha

AU - Lust, John A.

AU - Wellik, Linda

AU - Witzig, Thomas Elmer

AU - Gertz, Morie

AU - Kyle, Robert A.

AU - Greipp, Philip R.

AU - Rajkumar, S Vincent

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AB - Angiogenesis plays an important role in the biology of multiple myeloma (MM) and has prognostic importance in this disease. Solitary plasmacytoma is a localized plasma cell malignancy that progresses to MM in a significant number of patients. We examined if angiogenesis is increased in solitary plasmacytoma and if it can help identify patients likely to progress to myeloma. We studied angiogenesis in plasmacytoma biopsy samples and bone marrow biopsies from 25 patients. High-grade angiogenesis was present in 64% of plasmacytomas. In contrast, bone marrow angiogenesis was low in all patients. Patients with high-grade angiogenesis in the plasmacytoma sample were more likely to progress to myeloma and had a shorter progression-free survival compared with patients with low-grade angiogenesis (P = .02). Angiogenesis is increased in solitary plasmacytoma and is a significant predictor of progression to myeloma and provides further evidence of its importance in the pathogenesis of myeloma.

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