Prognostic significance of lymphatic, vascular and perineural invasion for bladder cancer patients treated by radical cystectomy

Prasuna Muppa, Sounak Gupta, Igor Frank, Stephen A. Boorjian, Robert Jeffrey Karnes, R. Houston Thompson, Prabin Thapa, Robert F. Tarrell, Loren P. Herrera Hernandez, Rafael E Jimenez, John C. Cheville

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In radical cystectomy specimens with bladder cancer, lymphatic and vascular invasion are often reported as ‘angiolymphatic’ or ‘lymphovascular’ invasion, terms that combine the findings of tumour within simple endothelial-lined lymphatic spaces and tumour within muscle-lined blood vessels. It is unclear if these patterns of invasion have different prognostic significance. In addition, there are conflicting data regarding the significance of lymphatic, vascular and perineural invasion in patients with bladder cancer. Herein, we studied 1504 patients treated by radical cystectomy for bladder cancer at our institution and followed for a mean of 10.6 years. Cases were re-reviewed by a urological pathologist for lymphatic invasion defined as tumour within a non-muscle-lined endothelial-lined lymphatic space, vascular invasion defined as tumour in a muscle-lined blood vessel, and perineural invasion defined as tumour within the perineural sheath. Associations of clinical and pathological features with bladder cancer death were evaluated using Cox proportional hazards regression models and summarised with hazard ratios and 95% confidence intervals. Survival was estimated by the Kaplan–Meier method. Multivariate analysis showed that lymphatic and vascular invasion but not perineural invasion were significantly associated with cancer specific survival (p < 0.0001 and p = 0.02, respectively). There was a significant association of lymphatic and vascular invasion but not perineural invasion with involved regional lymph nodes (p < 0.0001 and p = 0.004, respectively). In patients with metastasis to regional lymph nodes, lymphatic invasion remained significantly associated with outcome (p = 0.02). The frequency of lymphatic and vascular invasion varied amongst histological subtypes of bladder cancer. Vascular and lymphatic invasion should be clearly defined and reported for radical cystectomy specimens containing bladder cancer.

Original languageEnglish (US)
Pages (from-to)259-266
Number of pages8
JournalPathology
Volume49
Issue number3
DOIs
StatePublished - Apr 1 2017
Externally publishedYes

Fingerprint

Cystectomy
Urinary Bladder Neoplasms
Blood Vessels
Neoplasms
Lymph Nodes
Muscles
Survival
Proportional Hazards Models
Multivariate Analysis
Confidence Intervals
Neoplasm Metastasis

Keywords

  • lymphatic invasion
  • perineural invasion
  • radical cystectomy
  • recurrence
  • survival
  • Urothelial cancer
  • vascular invasion

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

Prognostic significance of lymphatic, vascular and perineural invasion for bladder cancer patients treated by radical cystectomy. / Muppa, Prasuna; Gupta, Sounak; Frank, Igor; Boorjian, Stephen A.; Karnes, Robert Jeffrey; Thompson, R. Houston; Thapa, Prabin; Tarrell, Robert F.; Herrera Hernandez, Loren P.; Jimenez, Rafael E; Cheville, John C.

In: Pathology, Vol. 49, No. 3, 01.04.2017, p. 259-266.

Research output: Contribution to journalArticle

Muppa, P, Gupta, S, Frank, I, Boorjian, SA, Karnes, RJ, Thompson, RH, Thapa, P, Tarrell, RF, Herrera Hernandez, LP, Jimenez, RE & Cheville, JC 2017, 'Prognostic significance of lymphatic, vascular and perineural invasion for bladder cancer patients treated by radical cystectomy', Pathology, vol. 49, no. 3, pp. 259-266. https://doi.org/10.1016/j.pathol.2016.12.347
Muppa, Prasuna ; Gupta, Sounak ; Frank, Igor ; Boorjian, Stephen A. ; Karnes, Robert Jeffrey ; Thompson, R. Houston ; Thapa, Prabin ; Tarrell, Robert F. ; Herrera Hernandez, Loren P. ; Jimenez, Rafael E ; Cheville, John C. / Prognostic significance of lymphatic, vascular and perineural invasion for bladder cancer patients treated by radical cystectomy. In: Pathology. 2017 ; Vol. 49, No. 3. pp. 259-266.
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AU - Karnes, Robert Jeffrey

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AU - Thapa, Prabin

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