TY - JOUR
T1 - Prognostic significance of histologic classification and grading of epithelial malignancies of the ovary
AU - Malkasian, George D.
AU - Melton, L. Joseph
AU - O'Brien, Peter C.
AU - Greene, Mark H.
N1 - Funding Information:
From the Department of Obstetrics and Gynecology and the Depart-ment of Medical Statistics and Epidemiology, Mayo Clinic and Mayo Foundation, and the National Cancer Institute, Environ-mental Epidemiology Branch. Supported in part by National Cancer Institute Grant N01-CP-01057. Presented at the Fifty-first Annual Meeting of The Central Associa-tion <if Obstetricians and Gynecologists, Colorado Springs, Col-orado, October 14-16,1983. Reprint requests: Dr. George D. Malkasian, Mayo Clinic, Rochester, MN 55905.
PY - 1984/6/1
Y1 - 1984/6/1
N2 - Overall survival in 1938 women with epithelial ovarian cancer receiving primary treatment at Mayo Clinic was 35% at 5 years, 28% at 10 years, and 15% at 25 years. For most histologic cell types, observed differences in survival were more apparent than real since the behavior of different cell types was similar when compared stage for stage and grade for grade. Mucinous cystadenocarcinomas tended to be low grade and low stage, while serous cystadenocarcinomas tended to be high grade and high stage. For Stage I disease, factors other than cell type seemed to be more important in determining survival; specifically. Stage IA1 patients did significantly better than all other Stage I patients. In Stage III disease, the amount of residual tumor made a significant difference in survival for all grades. In Stage IV disease, the amount of residual made a highly significant difference in survival for grade 1 disease.
AB - Overall survival in 1938 women with epithelial ovarian cancer receiving primary treatment at Mayo Clinic was 35% at 5 years, 28% at 10 years, and 15% at 25 years. For most histologic cell types, observed differences in survival were more apparent than real since the behavior of different cell types was similar when compared stage for stage and grade for grade. Mucinous cystadenocarcinomas tended to be low grade and low stage, while serous cystadenocarcinomas tended to be high grade and high stage. For Stage I disease, factors other than cell type seemed to be more important in determining survival; specifically. Stage IA1 patients did significantly better than all other Stage I patients. In Stage III disease, the amount of residual tumor made a significant difference in survival for all grades. In Stage IV disease, the amount of residual made a highly significant difference in survival for grade 1 disease.
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U2 - 10.1016/0002-9378(84)90227-8
DO - 10.1016/0002-9378(84)90227-8
M3 - Article
C2 - 6328995
AN - SCOPUS:0021269124
SN - 0002-9378
VL - 149
SP - 274
EP - 284
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 3
ER -