Prognostic Implications of Left Atrial Enlargement in Degenerative Mitral Regurgitation

Benjamin Essayagh, Clémence Antoine, Giovanni Benfari, David Messika-Zeitoun, Hector I Michelena, Thierry Le Tourneau, Sunil Mankad, Christophe M. Tribouilloy, Prabin Thapa, Maurice E Sarano

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Left atrial enlargement is frequent in degenerative mitral regurgitation (DMR), but its link to outcomes remains unproven in routine clinical practice. OBJECTIVES: The purpose of this study was to assess whether left atrial volume index (LAVI) measured in routine clinical practice of multiple sonographers/cardiologists is associated independently with DMR survival. METHODS: A cohort of 5,769 (63 ± 16 years, 47% women) consecutive patients with degenerative mitral valve disease, in whom LAVI was prospectively measured, was enrolled and the long-term survival was analyzed. RESULTS: LAVI (43 ± 24 ml/m2) was widely distributed (<40 ml/m2 in 3,154 patients, 40 to 59 ml/m2 in 1,606, and ≥60 ml/m2 in 1,009). Overall survival throughout follow-up (10-year 66 ± 1%) was strongly associated with LAVI (79 ± 1% vs. 65 ± 2% and 54 ± 2% for LAVI <40, 40 to 59, and ≥60 ml/m2, respectively; p < 0.0001) even after comprehensive adjustment, including for DMR severity (adjusted hazard ratio [HR]: 1.05 [95% confidence interval (CI): 1.03 to 1.08] per 10 ml/m2; p < 0.0001). Mortality under medical management was profoundly affected by LAVI (adjusted HR: 1.07 [95% CI: 1.04 to 1.10] per 10 ml/mm2 and 1.55 [95% CI: 1.31 to 1.84] for LAVI ≥60 ml/m2 vs. <40 ml/m2; both p < 0.0001) incrementally to adjusting variables (p < 0.0001) and in all subgroups, particularly sinus rhythm (adjusted HR: 1.25 [95% CI: 1.21 to 1.28]) or atrial fibrillation (adjusted HR: 1.10 [95% CI: 1.06 to 1.13] per 10 ml/m2; both p < 0.0001). Thresholds of excess mortality in spline curve analysis were approximated at 40 ml/m2 in all subgroups. Survival markedly improved after mitral surgery (time-dependent adjusted HR: 0.43 [95% CI: 0.36 to 0.53]; p < 0.0001) but remained modestly linked to LAVI (10-year survival 85 ± 3% vs. 86 ± 2% and 75 ± 3% for LAVI <40, 40 to 59, and ≥60 ml/m2, respectively; p < 0.0001). CONCLUSIONS: The frequent left atrial enlargement of DMR as measured by LAVI in routine practice displays, overall and in all subsets, a powerful, incremental, and independent link to excess mortality, which is partially alleviated by mitral surgery. Hence, LAVI measurement should be part of routine DMR evaluation and the clinical decision-making process.

Original languageEnglish (US)
Pages (from-to)858-870
Number of pages13
JournalJournal of the American College of Cardiology
Volume74
Issue number7
DOIs
StatePublished - Aug 20 2019

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Mitral Valve Insufficiency
Confidence Intervals
Survival
Mortality
Mitral Valve
Atrial Fibrillation

Keywords

  • echocardiography
  • left atrium
  • mitral regurgitation
  • mitral valve surgery
  • survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Prognostic Implications of Left Atrial Enlargement in Degenerative Mitral Regurgitation. / Essayagh, Benjamin; Antoine, Clémence; Benfari, Giovanni; Messika-Zeitoun, David; Michelena, Hector I; Le Tourneau, Thierry; Mankad, Sunil; Tribouilloy, Christophe M.; Thapa, Prabin; Sarano, Maurice E.

In: Journal of the American College of Cardiology, Vol. 74, No. 7, 20.08.2019, p. 858-870.

Research output: Contribution to journalArticle

Essayagh, B, Antoine, C, Benfari, G, Messika-Zeitoun, D, Michelena, HI, Le Tourneau, T, Mankad, S, Tribouilloy, CM, Thapa, P & Sarano, ME 2019, 'Prognostic Implications of Left Atrial Enlargement in Degenerative Mitral Regurgitation', Journal of the American College of Cardiology, vol. 74, no. 7, pp. 858-870. https://doi.org/10.1016/j.jacc.2019.06.032
Essayagh, Benjamin ; Antoine, Clémence ; Benfari, Giovanni ; Messika-Zeitoun, David ; Michelena, Hector I ; Le Tourneau, Thierry ; Mankad, Sunil ; Tribouilloy, Christophe M. ; Thapa, Prabin ; Sarano, Maurice E. / Prognostic Implications of Left Atrial Enlargement in Degenerative Mitral Regurgitation. In: Journal of the American College of Cardiology. 2019 ; Vol. 74, No. 7. pp. 858-870.
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abstract = "BACKGROUND: Left atrial enlargement is frequent in degenerative mitral regurgitation (DMR), but its link to outcomes remains unproven in routine clinical practice. OBJECTIVES: The purpose of this study was to assess whether left atrial volume index (LAVI) measured in routine clinical practice of multiple sonographers/cardiologists is associated independently with DMR survival. METHODS: A cohort of 5,769 (63 ± 16 years, 47{\%} women) consecutive patients with degenerative mitral valve disease, in whom LAVI was prospectively measured, was enrolled and the long-term survival was analyzed. RESULTS: LAVI (43 ± 24 ml/m2) was widely distributed (<40 ml/m2 in 3,154 patients, 40 to 59 ml/m2 in 1,606, and ≥60 ml/m2 in 1,009). Overall survival throughout follow-up (10-year 66 ± 1{\%}) was strongly associated with LAVI (79 ± 1{\%} vs. 65 ± 2{\%} and 54 ± 2{\%} for LAVI <40, 40 to 59, and ≥60 ml/m2, respectively; p < 0.0001) even after comprehensive adjustment, including for DMR severity (adjusted hazard ratio [HR]: 1.05 [95{\%} confidence interval (CI): 1.03 to 1.08] per 10 ml/m2; p < 0.0001). Mortality under medical management was profoundly affected by LAVI (adjusted HR: 1.07 [95{\%} CI: 1.04 to 1.10] per 10 ml/mm2 and 1.55 [95{\%} CI: 1.31 to 1.84] for LAVI ≥60 ml/m2 vs. <40 ml/m2; both p < 0.0001) incrementally to adjusting variables (p < 0.0001) and in all subgroups, particularly sinus rhythm (adjusted HR: 1.25 [95{\%} CI: 1.21 to 1.28]) or atrial fibrillation (adjusted HR: 1.10 [95{\%} CI: 1.06 to 1.13] per 10 ml/m2; both p < 0.0001). Thresholds of excess mortality in spline curve analysis were approximated at 40 ml/m2 in all subgroups. Survival markedly improved after mitral surgery (time-dependent adjusted HR: 0.43 [95{\%} CI: 0.36 to 0.53]; p < 0.0001) but remained modestly linked to LAVI (10-year survival 85 ± 3{\%} vs. 86 ± 2{\%} and 75 ± 3{\%} for LAVI <40, 40 to 59, and ≥60 ml/m2, respectively; p < 0.0001). CONCLUSIONS: The frequent left atrial enlargement of DMR as measured by LAVI in routine practice displays, overall and in all subsets, a powerful, incremental, and independent link to excess mortality, which is partially alleviated by mitral surgery. Hence, LAVI measurement should be part of routine DMR evaluation and the clinical decision-making process.",
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author = "Benjamin Essayagh and Cl{\'e}mence Antoine and Giovanni Benfari and David Messika-Zeitoun and Michelena, {Hector I} and {Le Tourneau}, Thierry and Sunil Mankad and Tribouilloy, {Christophe M.} and Prabin Thapa and Sarano, {Maurice E}",
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TY - JOUR

T1 - Prognostic Implications of Left Atrial Enlargement in Degenerative Mitral Regurgitation

AU - Essayagh, Benjamin

AU - Antoine, Clémence

AU - Benfari, Giovanni

AU - Messika-Zeitoun, David

AU - Michelena, Hector I

AU - Le Tourneau, Thierry

AU - Mankad, Sunil

AU - Tribouilloy, Christophe M.

AU - Thapa, Prabin

AU - Sarano, Maurice E

PY - 2019/8/20

Y1 - 2019/8/20

N2 - BACKGROUND: Left atrial enlargement is frequent in degenerative mitral regurgitation (DMR), but its link to outcomes remains unproven in routine clinical practice. OBJECTIVES: The purpose of this study was to assess whether left atrial volume index (LAVI) measured in routine clinical practice of multiple sonographers/cardiologists is associated independently with DMR survival. METHODS: A cohort of 5,769 (63 ± 16 years, 47% women) consecutive patients with degenerative mitral valve disease, in whom LAVI was prospectively measured, was enrolled and the long-term survival was analyzed. RESULTS: LAVI (43 ± 24 ml/m2) was widely distributed (<40 ml/m2 in 3,154 patients, 40 to 59 ml/m2 in 1,606, and ≥60 ml/m2 in 1,009). Overall survival throughout follow-up (10-year 66 ± 1%) was strongly associated with LAVI (79 ± 1% vs. 65 ± 2% and 54 ± 2% for LAVI <40, 40 to 59, and ≥60 ml/m2, respectively; p < 0.0001) even after comprehensive adjustment, including for DMR severity (adjusted hazard ratio [HR]: 1.05 [95% confidence interval (CI): 1.03 to 1.08] per 10 ml/m2; p < 0.0001). Mortality under medical management was profoundly affected by LAVI (adjusted HR: 1.07 [95% CI: 1.04 to 1.10] per 10 ml/mm2 and 1.55 [95% CI: 1.31 to 1.84] for LAVI ≥60 ml/m2 vs. <40 ml/m2; both p < 0.0001) incrementally to adjusting variables (p < 0.0001) and in all subgroups, particularly sinus rhythm (adjusted HR: 1.25 [95% CI: 1.21 to 1.28]) or atrial fibrillation (adjusted HR: 1.10 [95% CI: 1.06 to 1.13] per 10 ml/m2; both p < 0.0001). Thresholds of excess mortality in spline curve analysis were approximated at 40 ml/m2 in all subgroups. Survival markedly improved after mitral surgery (time-dependent adjusted HR: 0.43 [95% CI: 0.36 to 0.53]; p < 0.0001) but remained modestly linked to LAVI (10-year survival 85 ± 3% vs. 86 ± 2% and 75 ± 3% for LAVI <40, 40 to 59, and ≥60 ml/m2, respectively; p < 0.0001). CONCLUSIONS: The frequent left atrial enlargement of DMR as measured by LAVI in routine practice displays, overall and in all subsets, a powerful, incremental, and independent link to excess mortality, which is partially alleviated by mitral surgery. Hence, LAVI measurement should be part of routine DMR evaluation and the clinical decision-making process.

AB - BACKGROUND: Left atrial enlargement is frequent in degenerative mitral regurgitation (DMR), but its link to outcomes remains unproven in routine clinical practice. OBJECTIVES: The purpose of this study was to assess whether left atrial volume index (LAVI) measured in routine clinical practice of multiple sonographers/cardiologists is associated independently with DMR survival. METHODS: A cohort of 5,769 (63 ± 16 years, 47% women) consecutive patients with degenerative mitral valve disease, in whom LAVI was prospectively measured, was enrolled and the long-term survival was analyzed. RESULTS: LAVI (43 ± 24 ml/m2) was widely distributed (<40 ml/m2 in 3,154 patients, 40 to 59 ml/m2 in 1,606, and ≥60 ml/m2 in 1,009). Overall survival throughout follow-up (10-year 66 ± 1%) was strongly associated with LAVI (79 ± 1% vs. 65 ± 2% and 54 ± 2% for LAVI <40, 40 to 59, and ≥60 ml/m2, respectively; p < 0.0001) even after comprehensive adjustment, including for DMR severity (adjusted hazard ratio [HR]: 1.05 [95% confidence interval (CI): 1.03 to 1.08] per 10 ml/m2; p < 0.0001). Mortality under medical management was profoundly affected by LAVI (adjusted HR: 1.07 [95% CI: 1.04 to 1.10] per 10 ml/mm2 and 1.55 [95% CI: 1.31 to 1.84] for LAVI ≥60 ml/m2 vs. <40 ml/m2; both p < 0.0001) incrementally to adjusting variables (p < 0.0001) and in all subgroups, particularly sinus rhythm (adjusted HR: 1.25 [95% CI: 1.21 to 1.28]) or atrial fibrillation (adjusted HR: 1.10 [95% CI: 1.06 to 1.13] per 10 ml/m2; both p < 0.0001). Thresholds of excess mortality in spline curve analysis were approximated at 40 ml/m2 in all subgroups. Survival markedly improved after mitral surgery (time-dependent adjusted HR: 0.43 [95% CI: 0.36 to 0.53]; p < 0.0001) but remained modestly linked to LAVI (10-year survival 85 ± 3% vs. 86 ± 2% and 75 ± 3% for LAVI <40, 40 to 59, and ≥60 ml/m2, respectively; p < 0.0001). CONCLUSIONS: The frequent left atrial enlargement of DMR as measured by LAVI in routine practice displays, overall and in all subsets, a powerful, incremental, and independent link to excess mortality, which is partially alleviated by mitral surgery. Hence, LAVI measurement should be part of routine DMR evaluation and the clinical decision-making process.

KW - echocardiography

KW - left atrium

KW - mitral regurgitation

KW - mitral valve surgery

KW - survival

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