Prognostic factors in survival of bladder cancer

Antonio Lopez‐Beltran, Gary A. Croghan, Ivana Crogkan, Robert P. Huben, Curtis Mettlin, John F. Gaeta

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Clinical and pathologic data of 36 patients with transitional cell carcinoma of the bladder were investigated to determine the significance on patient survival of these factors: pathologic grade and stage; the immunohistochemistry of eight cell and tumor markers; nuclear DNA flow cytometric parameters; and patient smoking status. The bivariate and multivariate statistical analysis significantly correlated patient survival rates with the immunohistochemical expression of blood group, isoantigens A (P < 0.05), O(H) (P = 0.001), the oncogene‐related protein ORP‐p21 (P < 0.05), the pathologic grade and stage (P = 0.002), and the tumor DNA ploidy (P < 0.05). Smoking status correlated aneuploidy (P < 0.05) and tumor expression of ORP‐p21 (P < 0.05) with the patient survival rate. Despite the relatively small number of patients in this study, the results suggest that the clinicopathologic variables are significant factors in survival of bladder cancer. Cancer 1992: 70:799–807.

Original languageEnglish (US)
Pages (from-to)799-807
Number of pages9
JournalCancer
Volume70
Issue number4
DOIs
StatePublished - Aug 15 1992

Keywords

  • DNA flow cytometry
  • bladder
  • cancer
  • immunohistochemistry
  • prognosis
  • smoking
  • tumor markers

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Lopez‐Beltran, A., Croghan, G. A., Crogkan, I., Huben, R. P., Mettlin, C., & Gaeta, J. F. (1992). Prognostic factors in survival of bladder cancer. Cancer, 70(4), 799-807. https://doi.org/10.1002/1097-0142(19920815)70:4<799::AID-CNCR2820700414>3.0.CO;2-F