Prognostic factors in head-and-neck cancer patients treated with surgery followed by intensity-modulated radiotherapy (IMRT), 3D-conformal radiotherapy, or conventional radiotherapy

Dirk Rades, Fabian Fehlauer, Junes Wroblesky, Dirk Albers, Steven E. Schild, Rainer Schmidt

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

In 148 head-and-neck cancer patients treated with surgery plus radiotherapy (RT), IMRT, 3D-conformal RT, and conventional RT and 10 potential prognostic factors were evaluated for overall survival (OS), metastasis-free survival (MFS), and loco-regional control (LC). On univariate analysis, ECOG performance status, T-stage, AJCC-stage, extent of resection, and pre-RT hemoglobin level (≥12 g/dl better than <12 g/dl) were significantly associated with treatment outcome, whereas RT technique had no significant impact. On multivariate analysis, performance status maintained significance for OS (P = 0.019), AJCC-stage for LC (P = 0.034), extent of resection for OS (P = 0.045) and MFS (P = 0.021), pre-RT hemoglobin for MFS (P < 0.001). IMRT was associated with less xerostomia than conformal RT and conventional RT (17% versus 63% and 73%, P = 0.037). Otherwise, acute and late toxicity was similar. Outcome was significantly associated with performance status, tumor stage, extent of resection, and pre-RT hemoglobin. The three radiation techniques provided similar disease control. IMRT was effective in significantly reducing xerostomia.

Original languageEnglish (US)
Pages (from-to)535-543
Number of pages9
JournalOral Oncology
Volume43
Issue number6
DOIs
StatePublished - Jul 1 2007

Keywords

  • 3D-Conformal radiotherapy
  • Conventional irradiation
  • Head-and-neck cancer
  • Intensity-modulated radiotherapy
  • Prognostic factors
  • Toxicity

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

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