Prognostic factors in bladder cancer: A pathologic, immunohistochemical, and DNA flow-cytometric study

A. Lopez-Beltran, G. A. Croghan, I. Croghan, A. Matilla, J. F. Gaeta

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Pathologic grade and stage, immunohistochemical analysis of eight cell and tumor markers, and DNA ploidy were studied in 36 cases of bladder cancer to determine the features of value in assessment of patients' survival. Tumors of high grade and advanced stage correlated with DNA aneuploidy, whereas low grade and early stage correlated with DNA diploidy when simultaneously evaluated with survival. In addition, blood group isoantigen A correlated with DNA ploidy in deceased patients, whereas blood group isoantigen H and oncogene-related protein p21 correlated well with DNA ploidy in surviving patients. Despite the relatively small number of cases studied, these results suggest that pathologic grade and stage and immunohistochemical analysis of blood group isoantigens A and H and oncogene-related protein p21 hold additional value in the prediction of bladder cancer survival when evaluated simultaneously with DNA ploidy.

Original languageEnglish (US)
Pages (from-to)109-114
Number of pages6
JournalAmerican journal of clinical pathology
Volume102
Issue number1
DOIs
StatePublished - Jan 1 1994

Keywords

  • Bladder cancer survival
  • DNA ploidy
  • Immunohistochemistry
  • Pathology
  • Transitional cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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