TY - JOUR
T1 - Prognostic factors in bladder cancer
T2 - A pathologic, immunohistochemical, and DNA flow-cytometric study
AU - Lopez-Beltran, A.
AU - Croghan, G. A.
AU - Croghan, I.
AU - Matilla, A.
AU - Gaeta, J. F.
PY - 1994
Y1 - 1994
N2 - Pathologic grade and stage, immunohistochemical analysis of eight cell and tumor markers, and DNA ploidy were studied in 36 cases of bladder cancer to determine the features of value in assessment of patients' survival. Tumors of high grade and advanced stage correlated with DNA aneuploidy, whereas low grade and early stage correlated with DNA diploidy when simultaneously evaluated with survival. In addition, blood group isoantigen A correlated with DNA ploidy in deceased patients, whereas blood group isoantigen H and oncogene-related protein p21 correlated well with DNA ploidy in surviving patients. Despite the relatively small number of cases studied, these results suggest that pathologic grade and stage and immunohistochemical analysis of blood group isoantigens A and H and oncogene-related protein p21 hold additional value in the prediction of bladder cancer survival when evaluated simultaneously with DNA ploidy.
AB - Pathologic grade and stage, immunohistochemical analysis of eight cell and tumor markers, and DNA ploidy were studied in 36 cases of bladder cancer to determine the features of value in assessment of patients' survival. Tumors of high grade and advanced stage correlated with DNA aneuploidy, whereas low grade and early stage correlated with DNA diploidy when simultaneously evaluated with survival. In addition, blood group isoantigen A correlated with DNA ploidy in deceased patients, whereas blood group isoantigen H and oncogene-related protein p21 correlated well with DNA ploidy in surviving patients. Despite the relatively small number of cases studied, these results suggest that pathologic grade and stage and immunohistochemical analysis of blood group isoantigens A and H and oncogene-related protein p21 hold additional value in the prediction of bladder cancer survival when evaluated simultaneously with DNA ploidy.
KW - Bladder cancer survival
KW - DNA ploidy
KW - Immunohistochemistry
KW - Pathology
KW - Transitional cell carcinoma
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U2 - 10.1093/ajcp/102.1.109
DO - 10.1093/ajcp/102.1.109
M3 - Article
C2 - 8037155
AN - SCOPUS:0027985025
SN - 0002-9173
VL - 102
SP - 109
EP - 114
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 1
ER -