Prognostic factors after definitive radio(chemo)therapy of locally advanced head and neck cancer

Daniel Seidl, Stefan Janssen, Primoz Strojan, Amira Bajrovic, Steven E. Schild, Dirk Rades

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Aim: To identify predictors of locoregional control (LRC) and overall survival (OS) after definitive radio(chemo)therapy for squamous cell carcinoma of the head and neck (SCCHN). Patients and Methods: Two hundred and seventy-five patients were evaluated; 261 patients received radiochemotherapy with 30-40 mg/m2 of cisplatin weekly, three courses of cisplatin 100 mg/m2, two courses of cisplatin 5×20 mg/m2 or two courses of cisplatin 5×20 mg/m2plus 5-fluorouracil. Ten characteristics were analyzed: Pre-radiotherapy hemoglobin, T-/N-category, Karnofsky performance-score (KPS), gender, age, chemotherapy type, tumor site, grading and radiation dose. Results: On multivariate analyses, hemoglobin 12-14 g/dl (p=0.040), lower T-category (p=0.010), lower N-category (p=0.042) and female gender (p=0.006) were predictive of LRC. Hemoglobin >12 g/dl (p=0.020), lower N-category (p<0.001), KPS ≥80 (p<0.001), female gender (p=0.024) and cisplatin 100 mg/m2 or 5×20 mg/m2 (p<0.001) were predictors of improved OS. Conclusion: Predictors of LRC and OS were identified that can improve personalization of treatment. Since chemotherapy type was associated with OS, studies comparing different regimens are warranted.

Original languageEnglish (US)
Pages (from-to)2523-2526
Number of pages4
JournalAnticancer Research
Volume36
Issue number5
StatePublished - 2016

Keywords

  • Definitive radio(chemo) therapy
  • Locally advanced SCCHN
  • Locoregional control
  • Overall survival
  • Prognostic factors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Prognostic factors after definitive radio(chemo)therapy of locally advanced head and neck cancer'. Together they form a unique fingerprint.

  • Cite this

    Seidl, D., Janssen, S., Strojan, P., Bajrovic, A., Schild, S. E., & Rades, D. (2016). Prognostic factors after definitive radio(chemo)therapy of locally advanced head and neck cancer. Anticancer Research, 36(5), 2523-2526.