Prognostic and predictive impact of DNA mismatch repair in the management of colorectal cancer

Frank A Sinicrope, Zhineng Jayson Yang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Colorectal cancers develop via two major pathways that include chromosomal instability and microsatellite instability. Microsatellite instability occurs due to deficient DNA mismatch repair (MMR), which can be caused by epigenetic silencing of the MLH1 MMR gene in sporadic colorectal cancers or germline mutations in MMR genes that result in Lynch syndrome. While the molecular origin of deficient MMR differs, sporadic and Lynch syndrome tumors share similar pathological features and have a more favorable stage-adjusted prognosis compared with MMR-proficient cases. While controversy remains, there is evidence to suggest that deficient MMR may predict a lack of benefit from 5-fluorouracil-based adjuvant chemotherapy. The focus of this article is on the MMR phenotype and its prognostic and predictive implications for the management of patients with colorectal cancer.

Original languageEnglish (US)
Pages (from-to)467-474
Number of pages8
JournalFuture Oncology
Volume7
Issue number3
DOIs
StatePublished - Mar 2011

Fingerprint

DNA Mismatch Repair
Colorectal Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms
Microsatellite Instability
DNA Repair-Deficiency Disorders
Chromosomal Instability
Germ-Line Mutation
Adjuvant Chemotherapy
Epigenomics
Fluorouracil
Genes
Phenotype

Keywords

  • adjuvant therapy
  • colorectal cancer
  • DNA mismatch repair
  • Lynch syndrome
  • microsatellite instability

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Prognostic and predictive impact of DNA mismatch repair in the management of colorectal cancer. / Sinicrope, Frank A; Yang, Zhineng Jayson.

In: Future Oncology, Vol. 7, No. 3, 03.2011, p. 467-474.

Research output: Contribution to journalArticle

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