Prognosis with abnormal thallium images in the absence of significant coronary artery disease

Charles R. Cannan, Todd D. Miller, Timothy F. Christian, Kent R Bailey, Raymond J Gibbons

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In the presence of coronary artery disease (CAD), thallium imaging has been reported to add prognostic information that is independent of coronary anatomy. To investigate the prognostic importance of thallium imaging in the absence of significant CAD, 87 patients (65 men, 22 women) with abnormal thallium images without significant CAD were followed for a median duration of 22 months (range 11 to 50). Tomographic thallium images obtained immediately and 4 hours after exercise were interpreted by 2 experienced observers who graded thallium uptake in 24 segments in 3 views (short axis, horizontal long axis, vertical long axis) on a 5-point scale (normal; mildly, moderately, or severely reduced; absent). All patients had an abnormal thallium study, defined as a reversible defect of at least mild severity or a fixed defect of at least moderate severity seen in ≥ 2 views, or a combination of these, and a coronary angiogram with stenosis not ≥ 70% in diameter narrowing. Eighty-two patients had at least 1 reversible segment, and 26 patients had defects in ≥ 2 coronary artery distributions. During follow-up there were no deaths or myocardial infarctions. Coronary angioplasty and bypass surgery were performed in 2 patients. Three-year survival without myocardial infarction or revascularization was 97%. Patients with abnormal thallium images in the absence of significant CAD have an excellent short-term prognosis.

Original languageEnglish (US)
Pages (from-to)1276-1280
Number of pages5
JournalThe American Journal of Cardiology
Volume70
Issue number15
DOIs
StatePublished - Nov 15 1992

Fingerprint

Thallium
Coronary Artery Disease
Myocardial Infarction
Myocardial Revascularization
Angioplasty
Anatomy
Coronary Vessels
Angiography
Pathologic Constriction
Exercise
Survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Prognosis with abnormal thallium images in the absence of significant coronary artery disease. / Cannan, Charles R.; Miller, Todd D.; Christian, Timothy F.; Bailey, Kent R; Gibbons, Raymond J.

In: The American Journal of Cardiology, Vol. 70, No. 15, 15.11.1992, p. 1276-1280.

Research output: Contribution to journalArticle

Cannan, Charles R. ; Miller, Todd D. ; Christian, Timothy F. ; Bailey, Kent R ; Gibbons, Raymond J. / Prognosis with abnormal thallium images in the absence of significant coronary artery disease. In: The American Journal of Cardiology. 1992 ; Vol. 70, No. 15. pp. 1276-1280.
@article{cef9efde9d8e476f8c9e4a0ebef3c2e0,
title = "Prognosis with abnormal thallium images in the absence of significant coronary artery disease",
abstract = "In the presence of coronary artery disease (CAD), thallium imaging has been reported to add prognostic information that is independent of coronary anatomy. To investigate the prognostic importance of thallium imaging in the absence of significant CAD, 87 patients (65 men, 22 women) with abnormal thallium images without significant CAD were followed for a median duration of 22 months (range 11 to 50). Tomographic thallium images obtained immediately and 4 hours after exercise were interpreted by 2 experienced observers who graded thallium uptake in 24 segments in 3 views (short axis, horizontal long axis, vertical long axis) on a 5-point scale (normal; mildly, moderately, or severely reduced; absent). All patients had an abnormal thallium study, defined as a reversible defect of at least mild severity or a fixed defect of at least moderate severity seen in ≥ 2 views, or a combination of these, and a coronary angiogram with stenosis not ≥ 70{\%} in diameter narrowing. Eighty-two patients had at least 1 reversible segment, and 26 patients had defects in ≥ 2 coronary artery distributions. During follow-up there were no deaths or myocardial infarctions. Coronary angioplasty and bypass surgery were performed in 2 patients. Three-year survival without myocardial infarction or revascularization was 97{\%}. Patients with abnormal thallium images in the absence of significant CAD have an excellent short-term prognosis.",
author = "Cannan, {Charles R.} and Miller, {Todd D.} and Christian, {Timothy F.} and Bailey, {Kent R} and Gibbons, {Raymond J}",
year = "1992",
month = "11",
day = "15",
doi = "10.1016/0002-9149(92)90761-M",
language = "English (US)",
volume = "70",
pages = "1276--1280",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "15",

}

TY - JOUR

T1 - Prognosis with abnormal thallium images in the absence of significant coronary artery disease

AU - Cannan, Charles R.

AU - Miller, Todd D.

AU - Christian, Timothy F.

AU - Bailey, Kent R

AU - Gibbons, Raymond J

PY - 1992/11/15

Y1 - 1992/11/15

N2 - In the presence of coronary artery disease (CAD), thallium imaging has been reported to add prognostic information that is independent of coronary anatomy. To investigate the prognostic importance of thallium imaging in the absence of significant CAD, 87 patients (65 men, 22 women) with abnormal thallium images without significant CAD were followed for a median duration of 22 months (range 11 to 50). Tomographic thallium images obtained immediately and 4 hours after exercise were interpreted by 2 experienced observers who graded thallium uptake in 24 segments in 3 views (short axis, horizontal long axis, vertical long axis) on a 5-point scale (normal; mildly, moderately, or severely reduced; absent). All patients had an abnormal thallium study, defined as a reversible defect of at least mild severity or a fixed defect of at least moderate severity seen in ≥ 2 views, or a combination of these, and a coronary angiogram with stenosis not ≥ 70% in diameter narrowing. Eighty-two patients had at least 1 reversible segment, and 26 patients had defects in ≥ 2 coronary artery distributions. During follow-up there were no deaths or myocardial infarctions. Coronary angioplasty and bypass surgery were performed in 2 patients. Three-year survival without myocardial infarction or revascularization was 97%. Patients with abnormal thallium images in the absence of significant CAD have an excellent short-term prognosis.

AB - In the presence of coronary artery disease (CAD), thallium imaging has been reported to add prognostic information that is independent of coronary anatomy. To investigate the prognostic importance of thallium imaging in the absence of significant CAD, 87 patients (65 men, 22 women) with abnormal thallium images without significant CAD were followed for a median duration of 22 months (range 11 to 50). Tomographic thallium images obtained immediately and 4 hours after exercise were interpreted by 2 experienced observers who graded thallium uptake in 24 segments in 3 views (short axis, horizontal long axis, vertical long axis) on a 5-point scale (normal; mildly, moderately, or severely reduced; absent). All patients had an abnormal thallium study, defined as a reversible defect of at least mild severity or a fixed defect of at least moderate severity seen in ≥ 2 views, or a combination of these, and a coronary angiogram with stenosis not ≥ 70% in diameter narrowing. Eighty-two patients had at least 1 reversible segment, and 26 patients had defects in ≥ 2 coronary artery distributions. During follow-up there were no deaths or myocardial infarctions. Coronary angioplasty and bypass surgery were performed in 2 patients. Three-year survival without myocardial infarction or revascularization was 97%. Patients with abnormal thallium images in the absence of significant CAD have an excellent short-term prognosis.

UR - http://www.scopus.com/inward/record.url?scp=0026492947&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026492947&partnerID=8YFLogxK

U2 - 10.1016/0002-9149(92)90761-M

DO - 10.1016/0002-9149(92)90761-M

M3 - Article

C2 - 1442578

AN - SCOPUS:0026492947

VL - 70

SP - 1276

EP - 1280

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 15

ER -