Prognosis of seizures occurring in the first year

Anita N. Datta, Elaine C Wirrell

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

To determine whether predictors of neurodevelopmental outcome and the course of epilepsy can be identified in infants 1-12 months of age presenting with their first afebrile seizure, we collected demographic data, seizure details (type, frequency, duration, etiology, and treatment), developmental status, neurologic findings at presentation and follow-up, and electroencephalographic (EEG), neuroimaging, metabolic, hematologic, and chemistry test results by chart review, parental interview, and neurologic examination in 40/41 subjects (98%) presenting to our institution between January 1994 and December 1998. The mean duration of follow-up from onset of seizures was 29 months (S.D. = 17; range = 1-64). Predictors of developmental and neurologic abnormalities at follow-up included developmental delay and abnormal neurologic examination at presentation, infantile spasms, lack of response to antiepileptic drugs (AEDs), valproate use, and abnormal EEG or neuroimaging results. Predictors against seizure control and epilepsy remission and for the development of problematic seizures at follow-up included valproate use and lack of response to AEDs. Poor neurodevelopmental outcome of children with new-onset afebrile seizures in the first 1-12 months of age can be accurately predicted at diagnosis with the aid of EEG and neuroimaging studies. The course of epilepsy is more difficult to predict, but failure to respond to the first AED is worrisome. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)386-391
Number of pages6
JournalPediatric Neurology
Volume22
Issue number5
DOIs
StatePublished - May 2000
Externally publishedYes

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Seizures
Neuroimaging
Anticonvulsants
Epilepsy
Neurologic Examination
Valproic Acid
Nervous System Malformations
Infantile Spasms
Hematologic Tests
Neurologic Manifestations
Demography
Interviews
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

Prognosis of seizures occurring in the first year. / Datta, Anita N.; Wirrell, Elaine C.

In: Pediatric Neurology, Vol. 22, No. 5, 05.2000, p. 386-391.

Research output: Contribution to journalArticle

Datta, Anita N. ; Wirrell, Elaine C. / Prognosis of seizures occurring in the first year. In: Pediatric Neurology. 2000 ; Vol. 22, No. 5. pp. 386-391.
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