Prognosis of patients with good exercise capacity and mildly abnormal exercise echocardiography results: Identification of an at-risk subgroup

Robert B. McCully, Steve R. Ommen, Kyle W. Klarich, Kelli N. Burger, Douglas W. Mahoney, Patricia Pellikka

Research output: Contribution to journalArticle

3 Scopus citations


Background: Patients with good exercise capacity and mildly abnormal exercise echocardiography results have a favorable overall prognosis. Objective: We sought to define subgroups that might be at higher risk. Methods: We examined outcomes of 868 patients (women, < 5 metabolic equivalents; men, < 7 metabolic equivalents) with mild rest- or exercise-induced wall-motion abnormalities and evaluated potential predictors of time to cardiac death or nonfatal myocardial infarction (MI). Results: Mean age was 64 ± 10 years; 477 patients (55%) were men. Mean follow-up was 3.1 ± 1.5 years; cardiac event rate was 1.2% per person-year. A history of MI was the only significant predictor (risk ratio, 3.9; 95% confidence interval, 1.9-7.8; P =. 0001), with 1-, 3-, and 5-year event-free survival of 98.5% ± 1.1%, 92.6% ± 2.6%, and 83.3% ± 5.1%, respectively (event rate, 3.4%). Conclusions: Patients with a history of MI have a higher annual cardiac event rate and may benefit from reevaluation, whereas no history of MI connotes a favorable prognosis.

Original languageEnglish (US)
Pages (from-to)644-648
Number of pages5
JournalJournal of the American Society of Echocardiography
Issue number6
StatePublished - Jun 2005


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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