Prognosis of chronic ulcerative colitis in a community

Cynthia M Stonnington, S. F. Phillips, A. R. Zinsmeister, L. J. Melton

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Utilising the population based data resources of the Rochester Epidemiology Project, we estimated survival and risk of subsequent colon cancer in the 182 residents of Rochester, Minnesota, initally diagnosed with chronic ulcerative colitis (CUC) between 1935 and 1979. Twenty five (13.7%) had a proctocolectomy during the course of follow up. Three patients developed colorectal adenocarcinoma after the initial diagnosis of CUC (relative risk=1.9,95% CI 0.4-5.4). Excluding proctitis cases, the relative risk of cancer was 2.4 (95% CI 0.3-8.7). At last follow up, 37 (20.3%) were dead; only 10 patients had chronic ulcerative colitis mentioned on the death certificate. Overall survival was similar to that expected for the general population of like age and sex. Our results suggest that chronic ulcerative colitis in the community is typically a milder disease than would appear from hospital or referral centre series.

Original languageEnglish (US)
Pages (from-to)1261-1266
Number of pages6
JournalGut
Volume28
Issue number10
DOIs
StatePublished - 1987

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Ulcerative Colitis
Proctitis
Death Certificates
Survival
Colonic Neoplasms
Population
Epidemiology
Adenocarcinoma
Referral and Consultation
Neoplasms

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Gastroenterology

Cite this

Stonnington, C. M., Phillips, S. F., Zinsmeister, A. R., & Melton, L. J. (1987). Prognosis of chronic ulcerative colitis in a community. Gut, 28(10), 1261-1266. https://doi.org/10.1136/gut.28.10.1261

Prognosis of chronic ulcerative colitis in a community. / Stonnington, Cynthia M; Phillips, S. F.; Zinsmeister, A. R.; Melton, L. J.

In: Gut, Vol. 28, No. 10, 1987, p. 1261-1266.

Research output: Contribution to journalArticle

Stonnington, CM, Phillips, SF, Zinsmeister, AR & Melton, LJ 1987, 'Prognosis of chronic ulcerative colitis in a community', Gut, vol. 28, no. 10, pp. 1261-1266. https://doi.org/10.1136/gut.28.10.1261
Stonnington, Cynthia M ; Phillips, S. F. ; Zinsmeister, A. R. ; Melton, L. J. / Prognosis of chronic ulcerative colitis in a community. In: Gut. 1987 ; Vol. 28, No. 10. pp. 1261-1266.
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