Prognosis in patients with anaplastic oligoastrocytoma is associated with histologic grade

Jan Craig Buckner, Judith R. O'Fallon, Robert P. Dinapoli, Paula J. Schomberg, Gist Farr, Paul Schaefer, Caterina Giannini, Bernd W. Scheithauer, Karla V. Ballman

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Anaplastic oligoastrocytomas (AOA) are relatively uncommon high-grade gliomas. While oligodendroglial elements are thought to be associated with better outcomes, the magnitude of the difference is not clear. Methods: Between 1980 and 1999, Mayo Clinic and the NCCTG conducted 10 trials of radiation therapy and chemotherapy in adults with newly-diagnosed high-grade gliomas. All pathology slides were reviewed by one of the authors (BWS or CG). We grouped patients by cell type and grade, compared survival distributions by the log-rank statistic, and performed multiple variable analyses. Results: Of 1368 patients, 68 (5%) had AOA, including 21 Grade 3 (OA3) and 47 grade 4 (OA4), 153 (11%) had anaplastic astrocytoma (AA), and 1147 (84%) had glioblastoma multiforme (GBM). Patients with OA3 survived significantly longer than those with OA4 (P = 0.0001) or AA (P = 0.0044). Patients with OA4 lived significantly longer than those with GBM (P = 0.0005). The same differences were noted for PFS. Prognostic factors for survival identified by multiple variable analysis were histology, age, ECOG performance score, and extent of surgical resection, but not treatment administered. Conclusions: Patients with anaplastic oligoastrocytoma have distinct outcomes based upon grade (OA3 vs. OA4) and in comparison with pure astrocytoma (AA or GBM). Future trials which include more than one histologic entity need to report results by cell type and grade and account for the varying prognoses in interpreting treatment outcomes.

Original languageEnglish (US)
Pages (from-to)279-286
Number of pages8
JournalJournal of Neuro-Oncology
Volume84
Issue number3
DOIs
StatePublished - Sep 2007

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Astrocytoma
Glioblastoma
Glioma
Survival
Histology
Radiotherapy
Pathology
Drug Therapy
Therapeutics

Keywords

  • Anaplastic astrocytoma
  • Anaplastic oliogoastrocytoma
  • Glioblastoma multiforme

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neuroscience(all)

Cite this

Buckner, J. C., O'Fallon, J. R., Dinapoli, R. P., Schomberg, P. J., Farr, G., Schaefer, P., ... Ballman, K. V. (2007). Prognosis in patients with anaplastic oligoastrocytoma is associated with histologic grade. Journal of Neuro-Oncology, 84(3), 279-286. https://doi.org/10.1007/s11060-007-9370-y

Prognosis in patients with anaplastic oligoastrocytoma is associated with histologic grade. / Buckner, Jan Craig; O'Fallon, Judith R.; Dinapoli, Robert P.; Schomberg, Paula J.; Farr, Gist; Schaefer, Paul; Giannini, Caterina; Scheithauer, Bernd W.; Ballman, Karla V.

In: Journal of Neuro-Oncology, Vol. 84, No. 3, 09.2007, p. 279-286.

Research output: Contribution to journalArticle

Buckner, JC, O'Fallon, JR, Dinapoli, RP, Schomberg, PJ, Farr, G, Schaefer, P, Giannini, C, Scheithauer, BW & Ballman, KV 2007, 'Prognosis in patients with anaplastic oligoastrocytoma is associated with histologic grade', Journal of Neuro-Oncology, vol. 84, no. 3, pp. 279-286. https://doi.org/10.1007/s11060-007-9370-y
Buckner, Jan Craig ; O'Fallon, Judith R. ; Dinapoli, Robert P. ; Schomberg, Paula J. ; Farr, Gist ; Schaefer, Paul ; Giannini, Caterina ; Scheithauer, Bernd W. ; Ballman, Karla V. / Prognosis in patients with anaplastic oligoastrocytoma is associated with histologic grade. In: Journal of Neuro-Oncology. 2007 ; Vol. 84, No. 3. pp. 279-286.
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abstract = "Background: Anaplastic oligoastrocytomas (AOA) are relatively uncommon high-grade gliomas. While oligodendroglial elements are thought to be associated with better outcomes, the magnitude of the difference is not clear. Methods: Between 1980 and 1999, Mayo Clinic and the NCCTG conducted 10 trials of radiation therapy and chemotherapy in adults with newly-diagnosed high-grade gliomas. All pathology slides were reviewed by one of the authors (BWS or CG). We grouped patients by cell type and grade, compared survival distributions by the log-rank statistic, and performed multiple variable analyses. Results: Of 1368 patients, 68 (5{\%}) had AOA, including 21 Grade 3 (OA3) and 47 grade 4 (OA4), 153 (11{\%}) had anaplastic astrocytoma (AA), and 1147 (84{\%}) had glioblastoma multiforme (GBM). Patients with OA3 survived significantly longer than those with OA4 (P = 0.0001) or AA (P = 0.0044). Patients with OA4 lived significantly longer than those with GBM (P = 0.0005). The same differences were noted for PFS. Prognostic factors for survival identified by multiple variable analysis were histology, age, ECOG performance score, and extent of surgical resection, but not treatment administered. Conclusions: Patients with anaplastic oligoastrocytoma have distinct outcomes based upon grade (OA3 vs. OA4) and in comparison with pure astrocytoma (AA or GBM). Future trials which include more than one histologic entity need to report results by cell type and grade and account for the varying prognoses in interpreting treatment outcomes.",
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AU - Buckner, Jan Craig

AU - O'Fallon, Judith R.

AU - Dinapoli, Robert P.

AU - Schomberg, Paula J.

AU - Farr, Gist

AU - Schaefer, Paul

AU - Giannini, Caterina

AU - Scheithauer, Bernd W.

AU - Ballman, Karla V.

PY - 2007/9

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N2 - Background: Anaplastic oligoastrocytomas (AOA) are relatively uncommon high-grade gliomas. While oligodendroglial elements are thought to be associated with better outcomes, the magnitude of the difference is not clear. Methods: Between 1980 and 1999, Mayo Clinic and the NCCTG conducted 10 trials of radiation therapy and chemotherapy in adults with newly-diagnosed high-grade gliomas. All pathology slides were reviewed by one of the authors (BWS or CG). We grouped patients by cell type and grade, compared survival distributions by the log-rank statistic, and performed multiple variable analyses. Results: Of 1368 patients, 68 (5%) had AOA, including 21 Grade 3 (OA3) and 47 grade 4 (OA4), 153 (11%) had anaplastic astrocytoma (AA), and 1147 (84%) had glioblastoma multiforme (GBM). Patients with OA3 survived significantly longer than those with OA4 (P = 0.0001) or AA (P = 0.0044). Patients with OA4 lived significantly longer than those with GBM (P = 0.0005). The same differences were noted for PFS. Prognostic factors for survival identified by multiple variable analysis were histology, age, ECOG performance score, and extent of surgical resection, but not treatment administered. Conclusions: Patients with anaplastic oligoastrocytoma have distinct outcomes based upon grade (OA3 vs. OA4) and in comparison with pure astrocytoma (AA or GBM). Future trials which include more than one histologic entity need to report results by cell type and grade and account for the varying prognoses in interpreting treatment outcomes.

AB - Background: Anaplastic oligoastrocytomas (AOA) are relatively uncommon high-grade gliomas. While oligodendroglial elements are thought to be associated with better outcomes, the magnitude of the difference is not clear. Methods: Between 1980 and 1999, Mayo Clinic and the NCCTG conducted 10 trials of radiation therapy and chemotherapy in adults with newly-diagnosed high-grade gliomas. All pathology slides were reviewed by one of the authors (BWS or CG). We grouped patients by cell type and grade, compared survival distributions by the log-rank statistic, and performed multiple variable analyses. Results: Of 1368 patients, 68 (5%) had AOA, including 21 Grade 3 (OA3) and 47 grade 4 (OA4), 153 (11%) had anaplastic astrocytoma (AA), and 1147 (84%) had glioblastoma multiforme (GBM). Patients with OA3 survived significantly longer than those with OA4 (P = 0.0001) or AA (P = 0.0044). Patients with OA4 lived significantly longer than those with GBM (P = 0.0005). The same differences were noted for PFS. Prognostic factors for survival identified by multiple variable analysis were histology, age, ECOG performance score, and extent of surgical resection, but not treatment administered. Conclusions: Patients with anaplastic oligoastrocytoma have distinct outcomes based upon grade (OA3 vs. OA4) and in comparison with pure astrocytoma (AA or GBM). Future trials which include more than one histologic entity need to report results by cell type and grade and account for the varying prognoses in interpreting treatment outcomes.

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KW - Anaplastic oliogoastrocytoma

KW - Glioblastoma multiforme

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