TY - JOUR
T1 - Prognosis in Patients With an Abnormal Exercise Radionuclide Angiogram in the Absence of Significant Coronary Artery Disease
AU - Miller, Todd D.
AU - Taliercio, Charles P.
AU - Zinsmeister, Alan R.
AU - Gibbons, Raymond J.
PY - 1988
Y1 - 1988
N2 - To investigate the prognostic importance of abnormal exercise left ventricular function on radionuclide angiography in the absence of significant angiographic coronary artery disease, 79 consecutive patients with these findings were followed up for a mean of 25 months (range 12 to 55). All patients had 1) an ejection fraction at rest ≥0.40, 2) an ejection fraction that decreased with exercise or peak exercise ejection fraction >0.60, and 3) no significant coronary artery disease. The mean change in ejection fraction was a decrease of 0.07. In 63 patients (80%), the ejection fraction decreased during exercise; in 45 patients, it decreased by ≥0.05. Twenty patients (25 %) had a peak exercise ejection fraction >0.50. All patients were alive at follow-up study. One patient had a nonfatal myocardial infarction, and three patients were hospitalized for recurrent chest pain. No patient underwent coronary angioplasty or bypass surgery. The calculated infarction-free survival rate at 4 years by life table analysis was 97%. Patients with an abnormal exercise radionuclide angiogram in the absence of significant angiographic coronary artery disease have an excellent short-term prognosis.
AB - To investigate the prognostic importance of abnormal exercise left ventricular function on radionuclide angiography in the absence of significant angiographic coronary artery disease, 79 consecutive patients with these findings were followed up for a mean of 25 months (range 12 to 55). All patients had 1) an ejection fraction at rest ≥0.40, 2) an ejection fraction that decreased with exercise or peak exercise ejection fraction >0.60, and 3) no significant coronary artery disease. The mean change in ejection fraction was a decrease of 0.07. In 63 patients (80%), the ejection fraction decreased during exercise; in 45 patients, it decreased by ≥0.05. Twenty patients (25 %) had a peak exercise ejection fraction >0.50. All patients were alive at follow-up study. One patient had a nonfatal myocardial infarction, and three patients were hospitalized for recurrent chest pain. No patient underwent coronary angioplasty or bypass surgery. The calculated infarction-free survival rate at 4 years by life table analysis was 97%. Patients with an abnormal exercise radionuclide angiogram in the absence of significant angiographic coronary artery disease have an excellent short-term prognosis.
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U2 - 10.1016/S0735-1097(88)80049-4
DO - 10.1016/S0735-1097(88)80049-4
M3 - Article
C2 - 3403821
AN - SCOPUS:0023762798
SN - 0735-1097
VL - 12
SP - 637
EP - 641
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 3
ER -