Progesterone augments the venoconstrictor effect of Ruscus without altering adrenergic reactivity

Virginia M Miller, G. Marcelon, P. M. Vanhoutte

Research output: Contribution to journalArticle

4 Scopus citations


Chronic administration of oestrogen and/or progesterone does not affect adrenergic neurotransmission or contractions initiated by sympathomimetic amines in the cutaneous venous smooth muscle of the dog. However, contractions initiated by the venotropic Ruscus-extract are enhance following chronic exposure to progesterone, an affect that can be reversed by oestrogen. The contractions are mediated by an adrenergic and non-adrenergic component. The adrenergic component is enhanced by progesterone and decreased by oestrogen; the non-adrenergic component is most prominent when the serum-levels of the female steroid hormones are low.

Original languageEnglish (US)
Pages (from-to)261-268
Number of pages8
Issue number4
StatePublished - 1991


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this