Progesterone Augments the Venoconstrictor Effect of Ruscus without Altering Adrenergic Reactivity

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Chronic administration of oestrogen and/or progesterone does not affect adrenergic neurotransmission or contractions initiated by sympathomimetic amines in the cutaneous venous smooth muscle of the dog. However, contractions initiated by the venotropic Ruscus-extract are enhanced following chronic exposure to progesterone, an affect that can be reversed by oestrogen. The contractions are mediated by an adrenergic and non-adrenergic component. The adrenergic component is enhanced by progesterone and decreased by oestrogen; the non-adrenergic component is most prominent when the serum-levels of the female steroid hormones are low.

Original languageEnglish (US)
Pages (from-to)261-268
Number of pages8
JournalPhlebology
Volume6
Issue number4
DOIs
StatePublished - Dec 1991

Keywords

  • Ruscus-extract
  • canine saphenous veins
  • oestrogen
  • progesterone
  • sympathomimetic amines
  • venous contractility

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Progesterone Augments the Venoconstrictor Effect of Ruscus without Altering Adrenergic Reactivity'. Together they form a unique fingerprint.

Cite this