Abstract
Chronic administration of oestrogen and/or progesterone does not affect adrenergic neurotransmission or contractions initiated by sympathomimetic amines in the cutaneous venous smooth muscle of the dog. However, contractions initiated by the venotropic Ruscus-extract are enhanced following chronic exposure to progesterone, an affect that can be reversed by oestrogen. The contractions are mediated by an adrenergic and non-adrenergic component. The adrenergic component is enhanced by progesterone and decreased by oestrogen; the non-adrenergic component is most prominent when the serum-levels of the female steroid hormones are low.
Original language | English (US) |
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Pages (from-to) | 261-268 |
Number of pages | 8 |
Journal | Phlebology |
Volume | 6 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1991 |
Keywords
- Ruscus-extract
- canine saphenous veins
- oestrogen
- progesterone
- sympathomimetic amines
- venous contractility
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine