Prodynorphin gene polymorphisms in schizophrenia: An association study

G. Singh, V. Haluska, O. Kantarci, C. T. McMurray

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Family, adoption and twin studies support genetic component to pathogenesis of schizophrenia. Prodynorphin is one of the endogenous opiate precursors. Its products are neuromodulators that influence a variety of neurological functions including behavior. In addition some of their direct and indirect pharmacological action supports their role a candidate genes in schizophrenia. Objective: To conduct a systematic search of the prodynorphin gene for polymorphisms and mutations in schizophrenia patients and case controls and to correlate these with any association with this complex disorder. Method: Patient and control samples were collected by standard methods. Diagnosis was made using DSM-IV criteria after abstraction from extensive clinical records. Systematic search of entire gene for variations was done using Bi-directional fingerprinting method in the patients and controls. This was confirmed by sequencing. Results and Conclusions: We report several polymorphisms in the prodynorphin gene. One of these is a single nucleotide polymorphism in the promoter region that seems to increase the risk of developing schizophrenia two fold. The significance of these findings needs to be further elucidated.

Original languageEnglish (US)
Pages (from-to)620
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume105
Issue number7
StatePublished - Oct 8 2001

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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