Production of CD8+ T cell nonlytic suppressive factors by CD28, CD38, and HLA-DR subpopulations

Janina Q. Jiang, Sowmya Balasubramanian, Nanci C. Hawley-Foss, Andrew D. Badley, Kenneth L. Rosenthal, Karen F.T. Copeland

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

HIV infection may be modified by CD8+ T cells by the production of nonlytic antiviral factors. To determine subpopulations that mediate nonlytic, antiviral activity, we examined the production of β chemokines and of CD8 antiviral factor (CAF) by different subsets, using CD8+ cells derived from 24 HIV-1-infected and 25 uninfected individuals. Subjects with CD8+ cell counts greater than 200/μl produced increased levels of MIP-1α by CD8+CD28+, CD8+CD38-, and CD8+HLA-DR+ subsets as compared with uninfected controls. CD8+CD38- cells produced higher levels of MIP-1β and RANTES. CAF production was increased by CD8+CD38+ and CD8+HLA-DR+ cells of HIV-infected individuals as compared with uninfected controls. Chemokine production was increased by cells that do not express activation markers, whereas CAF activity was increased by cells expressing CD38 or HLA-DR. These findings shed light on CD8+ T cell noncytotoxic antiviral factor production during HIV infection.

Original languageEnglish (US)
Pages (from-to)497-502
Number of pages6
JournalAIDS Research and Human Retroviruses
Volume19
Issue number6
DOIs
StatePublished - Jun 1 2003

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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