Production of a polar metabolite of 1,25-dihydroxyvitamin D3 in a rat liver perfusion system

Rajiv Kumar, Sreeramulu Nagubandi, James M. Londowski

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

When radiolabeled 1,25-dihydroxyvitamin D3 is added to the perfusion medium of a rat liver perfusion system, a polar metabolite of 1,25-dihydroxyvitamin D3 is formed in the liver and excreted in the bile. Addition of radiolabeled 1,25-dihydroxyvitamin D3 to the perfusion medium without a liver in the circuit results in no formation of the polar metabolite. These data suggest that a polar metabolite of 1,25-dihydroxyvitamin D3 is formed in the liver prior to being excreted in bile. Moreover, it is likely that polar metabolites of 1,25-dihydroxyvitamin D3 present in the bile of rats in vivo are formed in the liver.

Original languageEnglish (US)
Pages (from-to)242-246
Number of pages5
JournalDigestive Diseases and Sciences
Volume26
Issue number3
DOIs
StatePublished - Mar 1981

    Fingerprint

ASJC Scopus subject areas

  • Gastroenterology

Cite this