TY - JOUR
T1 - Production of a polar metabolite of 1,25-dihydroxyvitamin D3 in a rat liver perfusion system
AU - Kumar, Rajiv
AU - Nagubandi, Sreeramulu
AU - Londowski, James M.
PY - 1981/3
Y1 - 1981/3
N2 - When radiolabeled 1,25-dihydroxyvitamin D3 is added to the perfusion medium of a rat liver perfusion system, a polar metabolite of 1,25-dihydroxyvitamin D3 is formed in the liver and excreted in the bile. Addition of radiolabeled 1,25-dihydroxyvitamin D3 to the perfusion medium without a liver in the circuit results in no formation of the polar metabolite. These data suggest that a polar metabolite of 1,25-dihydroxyvitamin D3 is formed in the liver prior to being excreted in bile. Moreover, it is likely that polar metabolites of 1,25-dihydroxyvitamin D3 present in the bile of rats in vivo are formed in the liver.
AB - When radiolabeled 1,25-dihydroxyvitamin D3 is added to the perfusion medium of a rat liver perfusion system, a polar metabolite of 1,25-dihydroxyvitamin D3 is formed in the liver and excreted in the bile. Addition of radiolabeled 1,25-dihydroxyvitamin D3 to the perfusion medium without a liver in the circuit results in no formation of the polar metabolite. These data suggest that a polar metabolite of 1,25-dihydroxyvitamin D3 is formed in the liver prior to being excreted in bile. Moreover, it is likely that polar metabolites of 1,25-dihydroxyvitamin D3 present in the bile of rats in vivo are formed in the liver.
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U2 - 10.1007/BF01391637
DO - 10.1007/BF01391637
M3 - Article
C2 - 6894570
AN - SCOPUS:0019436464
SN - 0163-2116
VL - 26
SP - 242
EP - 246
JO - Digestive diseases and sciences
JF - Digestive diseases and sciences
IS - 3
ER -