Production, degradation, and circulating levels of 1,25-dihydroxyvitamin D in health and in chronic glucocorticoid excess

E. Seeman, Rajiv Kumar, G. G. Hunder, M. Scott, H. Heath IIIrd, B. L. Riggs

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Abstract

The decreased intestinal absorption of calcium and accelerated bone loss associated with chronic glucocorticoid excess may be mediated by changes in vitamin D metabolism, leading to decreased availability of circulating 1,25-dihydroxyvitamin D. This hypothesis was examined in 14 patients with either endogenous or exogenous glucocorticoid excess. Analysis of paired serum samples (mean±SE) in 13 patients during euglucocorticoidism and during hyperglucocorticoidism showed that glucocorticoid excess resulted in small decreases of plasma 25-hydroxyvitamin D concentrations (22±2- 18±2 ng/ml; P < 0.05) but no significant changes in plasma 1,25-dihydroxyvitamin D (32±8-23±6 pg/ml) or serum immunoreactive parathyroid hormone (21±2-18±2 μleq/ml). Additionally, we studied plasma kinetics of [ 3H]1,25-dihydroxyvitamin D 3 after intravenous bolus administration in 10 hyperglucocorticoid patients and in 14 normal controls. Assessment with a three compartment model showed no significant abnormalities in production rates (hyperglucocorticoid patients 1.2±0.3 μg/d, controls 1.5±0.2 μg/d) or metabolic clearance rates (hyperglucocorticoid patients, 32±3 ml/min; controls, 31±3 ml/min). Moreover, there were no significant differences in cumulative excretion of radioactivity in urine (hyperglucocorticoid patients, 18±2%; controls, 14±2%) or feces (hyperglucocorticoid patients, 60±9%, controls, 54±6%). We conclude that glucocorticoid excess does not effect plasma levels, production, or degradation of 1,25(OH) 2D in humans. Thus, other mechanisms must be postulated to explain satisfactorily the abnormalities of bone structure and intestinal calcium absorption that may occur after chronic glucocorticoid therapy.

Original languageEnglish (US)
Pages (from-to)664-669
Number of pages6
JournalJournal of Clinical Investigation
Volume66
Issue number4
StatePublished - 1980

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ASJC Scopus subject areas

  • Medicine(all)

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