TY - JOUR
T1 - Production and optimization studies of cephalosporin C by solid state fermentation.
AU - Ellaiah, P.
AU - Premkumar, J.
AU - Kanthachari, P. V.
AU - Adinarayana, K.
PY - 2002
Y1 - 2002
N2 - Production of cephalosporin C employing a strain, Cephalosporium sp. NCIM 1039 under solid state fermentation was optimized. Different substrates like wheat bran, wheat grains, rice grains, barley and rice bran were studied to optimize the best substrate. Wheat bran showed the highest antibiotic yield. The physical and chemical parameters were optimized. The maximum productivity of cephalosporin C (750 U/g) was achieved by employing wheat bran and with optimized nutritional and process parameters such as potato starch as additive 1% w/w, urea as additive 1% w/w, incubation period of 7 days, incubation temperature at 30 degrees C, inoculum level 10% w/v, moisture content of solid substrate 80% and pH 7.0.
AB - Production of cephalosporin C employing a strain, Cephalosporium sp. NCIM 1039 under solid state fermentation was optimized. Different substrates like wheat bran, wheat grains, rice grains, barley and rice bran were studied to optimize the best substrate. Wheat bran showed the highest antibiotic yield. The physical and chemical parameters were optimized. The maximum productivity of cephalosporin C (750 U/g) was achieved by employing wheat bran and with optimized nutritional and process parameters such as potato starch as additive 1% w/w, urea as additive 1% w/w, incubation period of 7 days, incubation temperature at 30 degrees C, inoculum level 10% w/v, moisture content of solid substrate 80% and pH 7.0.
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M3 - Article
C2 - 15061587
AN - SCOPUS:2142645859
SN - 0018-1935
VL - 44
SP - 1
EP - 7
JO - Hindustan Antibiotics Bulletin
JF - Hindustan Antibiotics Bulletin
IS - 1-4
ER -