Proceedings of the International Consensus Conference on Breast Cancer Risk, Genetics, & Risk Management, April, 2007

Gordon F. Schwartz, Kevin S. Hughes, Henry T. Lynch, Carol J. Fabian, Ian S. Fentiman, Mark E. Robson, Susan M. Domchek, Lynn C. Hartmann, Roland Holland, David J. Winchester, Benjamin O. Anderson, Banu K. Arun, Harry Bartolink, Philip Bernard, Bernardo Bonanni, Blake Cady, Krishna B. Clough, Stephen A. Feig, Sylvia H. Heywang-Kobrunner, Anthony HowellClaudine Isaacs, Daniel B. Kopans, Robert E. Mansel, Shahla Masood, Juan P. Palazzo, Lawrence J. Solin, Michael Untch

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

A consensus conference including 30 experts was held in April, 2007, to discuss risk factors for breast cancer and their management. Four categories of risk were outlined, from "average" through "very high" risk, the latter including individuals with high penetrance BRCA1/2 gene mutations. Guidelines for management of patients in each of these categories were discussed, with the major portion of the conference devoted to individuals with BRCA1/2 mutations. Prevalence of these mutations in the general population was estimated to be 1 in 250-500 individuals, with an increased prevalence in Ashkenazi Jews and other founder groups. Risk-reduction strategies for these individuals included surveillance, with or without chemoprevention drugs, or surgical procedures to remove the organs at risk, ie, bilateral mastectomy and/or bilateral salpingo-oophorectomy. These risk reduction strategies were evaluated fully, and recommendations were made for the care of patients in each risk category. These guidelines for patient care were approved by the entire group of experts.

Original languageEnglish (US)
Pages (from-to)2627-2637
Number of pages11
JournalCancer
Volume113
Issue number10
DOIs
StatePublished - Nov 15 2008

Keywords

  • BRCA mutations
  • Breast cancer
  • International conference
  • Patient management guidelines
  • Risk factors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Schwartz, G. F., Hughes, K. S., Lynch, H. T., Fabian, C. J., Fentiman, I. S., Robson, M. E., Domchek, S. M., Hartmann, L. C., Holland, R., Winchester, D. J., Anderson, B. O., Arun, B. K., Bartolink, H., Bernard, P., Bonanni, B., Cady, B., Clough, K. B., Feig, S. A., Heywang-Kobrunner, S. H., ... Untch, M. (2008). Proceedings of the International Consensus Conference on Breast Cancer Risk, Genetics, & Risk Management, April, 2007. Cancer, 113(10), 2627-2637. https://doi.org/10.1002/cncr.23903