Probing the depths of cellular senescence

Darren J. Baker, John M. Sedivy

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Cellular senescence is a state of irreversible cell cycle arrest that has been documented to both suppress cancer and promote aging. Although not well understood, extensive nuclear changes, including the remodeling of chromatin, take place as cells become senescent. In this issue, Ivanov et al. (2013. J. Cell Biol. http://dx.doi.org/jcb.201212110) report that chromatin fragments are released from the nuclei of senescent cells and are subsequently targeted for processing through the autophagy/lysosomal pathway.

Original languageEnglish (US)
Pages (from-to)11-13
Number of pages3
JournalJournal of Cell Biology
Volume202
Issue number1
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Cell Biology

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