Probing the depths of cellular senescence

Darren J. Baker; John M. Sedivy

doi:10.1083/jcb.201305155

Probing the depths of cellular senescence

Darren J. Baker, John M. Sedivy

Pediatric and Adolescent Medicine

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Cellular senescence is a state of irreversible cell cycle arrest that has been documented to both suppress cancer and promote aging. Although not well understood, extensive nuclear changes, including the remodeling of chromatin, take place as cells become senescent. In this issue, Ivanov et al. (2013. J. Cell Biol. http://dx.doi.org/jcb.201212110) report that chromatin fragments are released from the nuclei of senescent cells and are subsequently targeted for processing through the autophagy/lysosomal pathway.

Original language	English (US)
Pages (from-to)	11-13
Number of pages	3
Journal	Journal of Cell Biology
Volume	202
Issue number	1
DOIs	https://doi.org/10.1083/jcb.201305155
State	Published - 2013

ASJC Scopus subject areas

Cell Biology

Access to Document

10.1083/jcb.201305155

Cite this

@article{d0cc0b48f1e24221abc96d2aa6867645,

title = "Probing the depths of cellular senescence",

abstract = "Cellular senescence is a state of irreversible cell cycle arrest that has been documented to both suppress cancer and promote aging. Although not well understood, extensive nuclear changes, including the remodeling of chromatin, take place as cells become senescent. In this issue, Ivanov et al. (2013. J. Cell Biol. http://dx.doi.org/jcb.201212110) report that chromatin fragments are released from the nuclei of senescent cells and are subsequently targeted for processing through the autophagy/lysosomal pathway.",

author = "Baker, {Darren J.} and Sedivy, {John M.}",

year = "2013",

doi = "10.1083/jcb.201305155",

language = "English (US)",

volume = "202",

pages = "11--13",

journal = "Journal of Cell Biology",

issn = "0021-9525",

publisher = "Rockefeller University Press",

number = "1",

}

TY - JOUR

T1 - Probing the depths of cellular senescence

AU - Baker, Darren J.

AU - Sedivy, John M.

PY - 2013

Y1 - 2013

N2 - Cellular senescence is a state of irreversible cell cycle arrest that has been documented to both suppress cancer and promote aging. Although not well understood, extensive nuclear changes, including the remodeling of chromatin, take place as cells become senescent. In this issue, Ivanov et al. (2013. J. Cell Biol. http://dx.doi.org/jcb.201212110) report that chromatin fragments are released from the nuclei of senescent cells and are subsequently targeted for processing through the autophagy/lysosomal pathway.

AB - Cellular senescence is a state of irreversible cell cycle arrest that has been documented to both suppress cancer and promote aging. Although not well understood, extensive nuclear changes, including the remodeling of chromatin, take place as cells become senescent. In this issue, Ivanov et al. (2013. J. Cell Biol. http://dx.doi.org/jcb.201212110) report that chromatin fragments are released from the nuclei of senescent cells and are subsequently targeted for processing through the autophagy/lysosomal pathway.

UR - http://www.scopus.com/inward/record.url?scp=84880604912&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880604912&partnerID=8YFLogxK

U2 - 10.1083/jcb.201305155

DO - 10.1083/jcb.201305155

M3 - Article

C2 - 23816622

AN - SCOPUS:84880604912

SN - 0021-9525

VL - 202

SP - 11

EP - 13

JO - Journal of Cell Biology

JF - Journal of Cell Biology

IS - 1

ER -

Probing the depths of cellular senescence

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this