Probe Oscillation Shear Wave Elastography

Initial In Vivo Results in Liver

Research output: Contribution to journalArticle

Abstract

Shear wave elastography methods are able to accurately measure tissue stiffness, allowing these techniques to monitor the progression of hepatic fibrosis. While many methods rely on acoustic radiation force (ARF) to generate shear waves for two-dimensional (2D) imaging, probe oscillation shear wave elastography (PROSE) provides an alternative approach by generating shear waves through continuous vibration of the ultrasound probe while simultaneously detecting the resulting motion. The generated shear wave field in in vivo liver is complicated, and the amplitude and quality of these shear waves can be influenced by the placement of the vibrating probe. To address these challenges, a real-time shear wave visualization tool was implemented to provide instantaneous visual feedback to optimize probe placement. Even with the real-time display, it was not possible to fully suppress residual motion with established filtering methods. To solve this problem, the shear wave signal in each frame was decoupled from motion from other sources through use of a parameter-free empirical mode decomposition (EMD) before calculating shear wave speeds. This method was evaluated in a phantom as well as in in vivo livers from five volunteers. PROSE results in the phantom as well as in vivo liver correlated well with independent measurements using the commercial General Electric Logiq E9 scanner.

Original languageEnglish (US)
JournalIEEE Transactions on Medical Imaging
DOIs
StateAccepted/In press - Dec 6 2017

Fingerprint

Elasticity Imaging Techniques
Shear waves
Liver
Sensory Feedback
Vibration
Acoustics
Volunteers
Fibrosis
Radiation
Vibrations (mechanical)
Visualization
Ultrasonics
Display devices
Stiffness
Tissue
Decomposition
Feedback

Keywords

  • high frame-rate
  • liver elastography
  • mechanical vibration
  • real-time imaging
  • ultrasound elastography

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering

Cite this

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title = "Probe Oscillation Shear Wave Elastography: Initial In Vivo Results in Liver",
abstract = "Shear wave elastography methods are able to accurately measure tissue stiffness, allowing these techniques to monitor the progression of hepatic fibrosis. While many methods rely on acoustic radiation force (ARF) to generate shear waves for two-dimensional (2D) imaging, probe oscillation shear wave elastography (PROSE) provides an alternative approach by generating shear waves through continuous vibration of the ultrasound probe while simultaneously detecting the resulting motion. The generated shear wave field in in vivo liver is complicated, and the amplitude and quality of these shear waves can be influenced by the placement of the vibrating probe. To address these challenges, a real-time shear wave visualization tool was implemented to provide instantaneous visual feedback to optimize probe placement. Even with the real-time display, it was not possible to fully suppress residual motion with established filtering methods. To solve this problem, the shear wave signal in each frame was decoupled from motion from other sources through use of a parameter-free empirical mode decomposition (EMD) before calculating shear wave speeds. This method was evaluated in a phantom as well as in in vivo livers from five volunteers. PROSE results in the phantom as well as in vivo liver correlated well with independent measurements using the commercial General Electric Logiq E9 scanner.",
keywords = "high frame-rate, liver elastography, mechanical vibration, real-time imaging, ultrasound elastography",
author = "Mellema, {Daniel C.} and Pengfei Song and Kinnick, {Randall R.} and Trazasko, {Joshua D} and Urban, {Matthew W} and Greenleaf, {James F} and Armando Manduca and Chen, {Shigao D}",
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AU - Mellema, Daniel C.

AU - Song, Pengfei

AU - Kinnick, Randall R.

AU - Trazasko, Joshua D

AU - Urban, Matthew W

AU - Greenleaf, James F

AU - Manduca, Armando

AU - Chen, Shigao D

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N2 - Shear wave elastography methods are able to accurately measure tissue stiffness, allowing these techniques to monitor the progression of hepatic fibrosis. While many methods rely on acoustic radiation force (ARF) to generate shear waves for two-dimensional (2D) imaging, probe oscillation shear wave elastography (PROSE) provides an alternative approach by generating shear waves through continuous vibration of the ultrasound probe while simultaneously detecting the resulting motion. The generated shear wave field in in vivo liver is complicated, and the amplitude and quality of these shear waves can be influenced by the placement of the vibrating probe. To address these challenges, a real-time shear wave visualization tool was implemented to provide instantaneous visual feedback to optimize probe placement. Even with the real-time display, it was not possible to fully suppress residual motion with established filtering methods. To solve this problem, the shear wave signal in each frame was decoupled from motion from other sources through use of a parameter-free empirical mode decomposition (EMD) before calculating shear wave speeds. This method was evaluated in a phantom as well as in in vivo livers from five volunteers. PROSE results in the phantom as well as in vivo liver correlated well with independent measurements using the commercial General Electric Logiq E9 scanner.

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