TY - JOUR
T1 - Probable RBD is increased in Parkinson's disease but not in essential tremor or restless legs syndrome
AU - Adler, Charles H.
AU - Hentz, Joseph G.
AU - Shill, Holly A.
AU - Sabbagh, Marwan N.
AU - Driver-Dunckley, Erika
AU - Evidente, Virgilio G.H.
AU - Jacobson, Sandra A.
AU - Beach, Thomas G.
AU - Boeve, Bradley
AU - Caviness, John N.
N1 - Funding Information:
This work was funded by the Arizona Biomedical Research Commission (contracts 4001, 05-901, 0011, and 1001 to the AZ PD Consortium), the Michael J. Fox Foundation for Parkinson’s Research (Prescott Family Initiative), the Arizona Department of Health Services (contract 211002 to the AZ Alzheimer’s Research Center), the National Institute on Aging ( P30 AG19610 Arizona Alzheimer’s Disease Core Center), the Mayo Clinic Foundation for Medical Education and Research , and the Sun Health Foundation .
PY - 2011/7
Y1 - 2011/7
N2 - Objective: Compare the frequency of REM sleep behavior disorder (RBD) and excessive daytime sleepiness (EDS) in Parkinson's disease (PD), restless legs syndrome (RLS), essential tremor (ET), and control subjects. Methods: Subjects enrolled in a longitudinal clinicopathologic study, and when available an informant, completed the Mayo Sleep Questionnaire, which asks "Have you ever been told that you act out your dreams?", and the Epworth Sleepiness Scale (ESS). Results: Probable RBD (based on informant response to the questionnaire) was much more frequent in PD (34/49, 69%, P < 0.001) than in RLS (6/30, 20%), ET (7/53, 13%), or control subjects (23/175, 13%), with an odds ratio of 11 for PD compared to controls. The mean ESS and the number of subjects with an ESS ≥ 10 was higher in PD (29/60, 48%, P < 0.001) and RLS (12/39, 31%, P < 0.001) compared with ET (12/93, 13%) and Controls (34/296, 11%). Conclusions: Probable RBD is much more frequent in PD with no evidence to suggest an increase in either RLS or ET. Given the evidence that RBD is a synucleinopathy, the lack of an increased frequency of RBD in subjects with ET or RLS suggests the majority of ET and RLS subjects are unlikely to be at increased risk for developing PD.
AB - Objective: Compare the frequency of REM sleep behavior disorder (RBD) and excessive daytime sleepiness (EDS) in Parkinson's disease (PD), restless legs syndrome (RLS), essential tremor (ET), and control subjects. Methods: Subjects enrolled in a longitudinal clinicopathologic study, and when available an informant, completed the Mayo Sleep Questionnaire, which asks "Have you ever been told that you act out your dreams?", and the Epworth Sleepiness Scale (ESS). Results: Probable RBD (based on informant response to the questionnaire) was much more frequent in PD (34/49, 69%, P < 0.001) than in RLS (6/30, 20%), ET (7/53, 13%), or control subjects (23/175, 13%), with an odds ratio of 11 for PD compared to controls. The mean ESS and the number of subjects with an ESS ≥ 10 was higher in PD (29/60, 48%, P < 0.001) and RLS (12/39, 31%, P < 0.001) compared with ET (12/93, 13%) and Controls (34/296, 11%). Conclusions: Probable RBD is much more frequent in PD with no evidence to suggest an increase in either RLS or ET. Given the evidence that RBD is a synucleinopathy, the lack of an increased frequency of RBD in subjects with ET or RLS suggests the majority of ET and RLS subjects are unlikely to be at increased risk for developing PD.
KW - Essential tremor
KW - Excessive daytime sleepiness
KW - Parkinson's disease
KW - REM sleep behavior disorder
KW - Restless legs syndrome
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U2 - 10.1016/j.parkreldis.2011.03.007
DO - 10.1016/j.parkreldis.2011.03.007
M3 - Article
C2 - 21482171
AN - SCOPUS:79959344260
SN - 1353-8020
VL - 17
SP - 456
EP - 458
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
IS - 6
ER -