Proarrhythmic effects of antiarrhythmic and non-antiarrhythmic drugs

J. William Schleifer, Komandoor Srivathsan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Many drugs, including both antiarrhythmic and non-antiarrhythmic medications, affect the ion channels and receptors of the heart with the potential to produce a proarrhythmic action. The proarrhythmic action of these drugs is influenced by electrolyte disturbances, hemodynamic abnormalities, and conditions affecting the metabolism and excretion of the medication. This chapter will discuss the mechanisms of proarrhythmic states commonly encountered, illustrate characteristic scenarios, and explain treatment strategies for medication-induced proarrhythmic states. As it is often difficult clinically to differentiate between arrhythmias occurring at therapeutic medication concentrations and those occurring at toxic levels, the treatment of antiarrhythmic toxicity is also discussed.

Original languageEnglish (US)
Title of host publicationPathophysiology and Pharmacotherapy of Cardiovascular Disease
PublisherSpringer International Publishing
Pages1015-1038
Number of pages24
ISBN (Electronic)9783319159614
ISBN (Print)9783319159607
DOIs
StatePublished - Jan 1 2015

Fingerprint

Poisons
Ion Channels
Pharmaceutical Preparations
Electrolytes
Cardiac Arrhythmias
Hemodynamics
Therapeutics

Keywords

  • Antiarrhythmic
  • Automaticit
  • Digoxin
  • Potassium channel
  • Sodium channel

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Schleifer, J. W., & Srivathsan, K. (2015). Proarrhythmic effects of antiarrhythmic and non-antiarrhythmic drugs. In Pathophysiology and Pharmacotherapy of Cardiovascular Disease (pp. 1015-1038). Springer International Publishing. https://doi.org/10.1007/978-3-319-15961-4_48

Proarrhythmic effects of antiarrhythmic and non-antiarrhythmic drugs. / Schleifer, J. William; Srivathsan, Komandoor.

Pathophysiology and Pharmacotherapy of Cardiovascular Disease. Springer International Publishing, 2015. p. 1015-1038.

Research output: Chapter in Book/Report/Conference proceedingChapter

Schleifer, JW & Srivathsan, K 2015, Proarrhythmic effects of antiarrhythmic and non-antiarrhythmic drugs. in Pathophysiology and Pharmacotherapy of Cardiovascular Disease. Springer International Publishing, pp. 1015-1038. https://doi.org/10.1007/978-3-319-15961-4_48
Schleifer JW, Srivathsan K. Proarrhythmic effects of antiarrhythmic and non-antiarrhythmic drugs. In Pathophysiology and Pharmacotherapy of Cardiovascular Disease. Springer International Publishing. 2015. p. 1015-1038 https://doi.org/10.1007/978-3-319-15961-4_48
Schleifer, J. William ; Srivathsan, Komandoor. / Proarrhythmic effects of antiarrhythmic and non-antiarrhythmic drugs. Pathophysiology and Pharmacotherapy of Cardiovascular Disease. Springer International Publishing, 2015. pp. 1015-1038
@inbook{f4d5c9808d734c17993e85ba3d59ff33,
title = "Proarrhythmic effects of antiarrhythmic and non-antiarrhythmic drugs",
abstract = "Many drugs, including both antiarrhythmic and non-antiarrhythmic medications, affect the ion channels and receptors of the heart with the potential to produce a proarrhythmic action. The proarrhythmic action of these drugs is influenced by electrolyte disturbances, hemodynamic abnormalities, and conditions affecting the metabolism and excretion of the medication. This chapter will discuss the mechanisms of proarrhythmic states commonly encountered, illustrate characteristic scenarios, and explain treatment strategies for medication-induced proarrhythmic states. As it is often difficult clinically to differentiate between arrhythmias occurring at therapeutic medication concentrations and those occurring at toxic levels, the treatment of antiarrhythmic toxicity is also discussed.",
keywords = "Antiarrhythmic, Automaticit, Digoxin, Potassium channel, Sodium channel",
author = "Schleifer, {J. William} and Komandoor Srivathsan",
year = "2015",
month = "1",
day = "1",
doi = "10.1007/978-3-319-15961-4_48",
language = "English (US)",
isbn = "9783319159607",
pages = "1015--1038",
booktitle = "Pathophysiology and Pharmacotherapy of Cardiovascular Disease",
publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Proarrhythmic effects of antiarrhythmic and non-antiarrhythmic drugs

AU - Schleifer, J. William

AU - Srivathsan, Komandoor

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Many drugs, including both antiarrhythmic and non-antiarrhythmic medications, affect the ion channels and receptors of the heart with the potential to produce a proarrhythmic action. The proarrhythmic action of these drugs is influenced by electrolyte disturbances, hemodynamic abnormalities, and conditions affecting the metabolism and excretion of the medication. This chapter will discuss the mechanisms of proarrhythmic states commonly encountered, illustrate characteristic scenarios, and explain treatment strategies for medication-induced proarrhythmic states. As it is often difficult clinically to differentiate between arrhythmias occurring at therapeutic medication concentrations and those occurring at toxic levels, the treatment of antiarrhythmic toxicity is also discussed.

AB - Many drugs, including both antiarrhythmic and non-antiarrhythmic medications, affect the ion channels and receptors of the heart with the potential to produce a proarrhythmic action. The proarrhythmic action of these drugs is influenced by electrolyte disturbances, hemodynamic abnormalities, and conditions affecting the metabolism and excretion of the medication. This chapter will discuss the mechanisms of proarrhythmic states commonly encountered, illustrate characteristic scenarios, and explain treatment strategies for medication-induced proarrhythmic states. As it is often difficult clinically to differentiate between arrhythmias occurring at therapeutic medication concentrations and those occurring at toxic levels, the treatment of antiarrhythmic toxicity is also discussed.

KW - Antiarrhythmic

KW - Automaticit

KW - Digoxin

KW - Potassium channel

KW - Sodium channel

UR - http://www.scopus.com/inward/record.url?scp=84944096699&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944096699&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-15961-4_48

DO - 10.1007/978-3-319-15961-4_48

M3 - Chapter

AN - SCOPUS:84944096699

SN - 9783319159607

SP - 1015

EP - 1038

BT - Pathophysiology and Pharmacotherapy of Cardiovascular Disease

PB - Springer International Publishing

ER -