Pro-angiogenic properties of europium(III) hydroxide nanorods

Chitta Ranjan Patra, Resham Bhattacharya, Sujata Patra, Nicholas E. Vlahakis, Alexandra Gabashvili, Yuri Koltypin, Aharon Gedanken, Priyabrata Mukherjee, Debabrata Mukhopadhyay

Research output: Contribution to journalArticle

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Abstract

A study was conducted to observe the unique pro-angiogenic properties of europium (III) hydroxide [EuIII(OH)3] nanorods, synthesized by a microwave technique, to understand the biological impact of lanthanide elements. These nanorods promote endothelial cell proliferation in vitro and vascular sprouting in vivo. Generation of ROS and activation of MAPK induced by these nanorods might be the plausible mechanism for angiogenesis. A detailed mechanistic study and in vivo experiments are in progress to elucidate more detailed physico-chemical and biological activities of these nanorods, as exploration continues in this research field in angiogenesis using inorganic compounds, with not a single report of an angiogenesis using inorganic nanoparticles. The new pro-angiogenic properties of inorganic [Eu III(OH)3] nanorods may also be used to develop new treatment treatment strategies for cardiovascular inchemic and limb ischemia-related diseases in future.

Original languageEnglish (US)
Pages (from-to)753-756
Number of pages4
JournalAdvanced Materials
Volume20
Issue number4
DOIs
StatePublished - Feb 18 2008

Fingerprint

Europium
Nanorods
Inorganic compounds
Lanthanoid Series Elements
Endothelial cells
Cell proliferation
Bioactivity
Rare earth elements
Chemical activation
Microwaves
hydroxide ion
Nanoparticles
Experiments

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Patra, C. R., Bhattacharya, R., Patra, S., Vlahakis, N. E., Gabashvili, A., Koltypin, Y., ... Mukhopadhyay, D. (2008). Pro-angiogenic properties of europium(III) hydroxide nanorods. Advanced Materials, 20(4), 753-756. https://doi.org/10.1002/adma.200701611

Pro-angiogenic properties of europium(III) hydroxide nanorods. / Patra, Chitta Ranjan; Bhattacharya, Resham; Patra, Sujata; Vlahakis, Nicholas E.; Gabashvili, Alexandra; Koltypin, Yuri; Gedanken, Aharon; Mukherjee, Priyabrata; Mukhopadhyay, Debabrata.

In: Advanced Materials, Vol. 20, No. 4, 18.02.2008, p. 753-756.

Research output: Contribution to journalArticle

Patra, CR, Bhattacharya, R, Patra, S, Vlahakis, NE, Gabashvili, A, Koltypin, Y, Gedanken, A, Mukherjee, P & Mukhopadhyay, D 2008, 'Pro-angiogenic properties of europium(III) hydroxide nanorods', Advanced Materials, vol. 20, no. 4, pp. 753-756. https://doi.org/10.1002/adma.200701611
Patra CR, Bhattacharya R, Patra S, Vlahakis NE, Gabashvili A, Koltypin Y et al. Pro-angiogenic properties of europium(III) hydroxide nanorods. Advanced Materials. 2008 Feb 18;20(4):753-756. https://doi.org/10.1002/adma.200701611
Patra, Chitta Ranjan ; Bhattacharya, Resham ; Patra, Sujata ; Vlahakis, Nicholas E. ; Gabashvili, Alexandra ; Koltypin, Yuri ; Gedanken, Aharon ; Mukherjee, Priyabrata ; Mukhopadhyay, Debabrata. / Pro-angiogenic properties of europium(III) hydroxide nanorods. In: Advanced Materials. 2008 ; Vol. 20, No. 4. pp. 753-756.
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