TY - JOUR
T1 - Pro-angiogenic properties of europium(III) hydroxide nanorods
AU - Patra, Chitta Ranjan
AU - Bhattacharya, Resham
AU - Patra, Sujata
AU - Vlahakis, Nicholas E.
AU - Gabashvili, Alexandra
AU - Koltypin, Yuri
AU - Gedanken, Aharon
AU - Mukherjee, Priyabrata
AU - Mukhopadhyay, Debabrata
PY - 2008/2/18
Y1 - 2008/2/18
N2 - A study was conducted to observe the unique pro-angiogenic properties of europium (III) hydroxide [EuIII(OH)3] nanorods, synthesized by a microwave technique, to understand the biological impact of lanthanide elements. These nanorods promote endothelial cell proliferation in vitro and vascular sprouting in vivo. Generation of ROS and activation of MAPK induced by these nanorods might be the plausible mechanism for angiogenesis. A detailed mechanistic study and in vivo experiments are in progress to elucidate more detailed physico-chemical and biological activities of these nanorods, as exploration continues in this research field in angiogenesis using inorganic compounds, with not a single report of an angiogenesis using inorganic nanoparticles. The new pro-angiogenic properties of inorganic [Eu III(OH)3] nanorods may also be used to develop new treatment treatment strategies for cardiovascular inchemic and limb ischemia-related diseases in future.
AB - A study was conducted to observe the unique pro-angiogenic properties of europium (III) hydroxide [EuIII(OH)3] nanorods, synthesized by a microwave technique, to understand the biological impact of lanthanide elements. These nanorods promote endothelial cell proliferation in vitro and vascular sprouting in vivo. Generation of ROS and activation of MAPK induced by these nanorods might be the plausible mechanism for angiogenesis. A detailed mechanistic study and in vivo experiments are in progress to elucidate more detailed physico-chemical and biological activities of these nanorods, as exploration continues in this research field in angiogenesis using inorganic compounds, with not a single report of an angiogenesis using inorganic nanoparticles. The new pro-angiogenic properties of inorganic [Eu III(OH)3] nanorods may also be used to develop new treatment treatment strategies for cardiovascular inchemic and limb ischemia-related diseases in future.
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U2 - 10.1002/adma.200701611
DO - 10.1002/adma.200701611
M3 - Article
AN - SCOPUS:51049097758
SN - 0935-9648
VL - 20
SP - 753
EP - 756
JO - Advanced Materials
JF - Advanced Materials
IS - 4
ER -