TY - JOUR
T1 - PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease
AU - Dermaut, Bart
AU - Croes, Esther A.
AU - Rademakers, Rosa
AU - Van den Broeck, Marleen V.
AU - Cruts, Marc
AU - Hofman, Albert
AU - Van Duijn, Cornelia M.
AU - Van Broeckhoven, Christine
PY - 2003/3/1
Y1 - 2003/3/1
N2 - We analyzed the PRNP M129V polymorphism in a Dutch population-based early-onset Alzheimer's disease sample. We observed a significant association between early-onset Alzheimer's disease and homozygosity of M129V (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.1-3.3; p = 0.02) with the highest risk for V homozygotes (OR, 3.2; 95% CI, 1.4-7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3-5.3; p < 0.01) and 3.5 (95% CI, 1.3-9.3; p = 0.01), respectively.
AB - We analyzed the PRNP M129V polymorphism in a Dutch population-based early-onset Alzheimer's disease sample. We observed a significant association between early-onset Alzheimer's disease and homozygosity of M129V (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.1-3.3; p = 0.02) with the highest risk for V homozygotes (OR, 3.2; 95% CI, 1.4-7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3-5.3; p < 0.01) and 3.5 (95% CI, 1.3-9.3; p = 0.01), respectively.
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U2 - 10.1002/ana.10507
DO - 10.1002/ana.10507
M3 - Article
C2 - 12601712
AN - SCOPUS:0037372585
SN - 0364-5134
VL - 53
SP - 409
EP - 412
JO - Annals of neurology
JF - Annals of neurology
IS - 3
ER -