PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease

Bart Dermaut, Esther A. Croes, Rosa V Rademakers, Marleen V. Van den Broeck, Marc Cruts, Albert Hofman, Cornelia M. Van Duijn, Christine Van Broeckhoven

Research output: Contribution to journalArticle

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Abstract

We analyzed the PRNP M129V polymorphism in a Dutch population-based early-onset Alzheimer's disease sample. We observed a significant association between early-onset Alzheimer's disease and homozygosity of M129V (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.1-3.3; p = 0.02) with the highest risk for V homozygotes (OR, 3.2; 95% CI, 1.4-7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3-5.3; p < 0.01) and 3.5 (95% CI, 1.3-9.3; p = 0.01), respectively.

Original languageEnglish (US)
Pages (from-to)409-412
Number of pages4
JournalAnnals of Neurology
Volume53
Issue number3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

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Alzheimer Disease
Confidence Intervals
Odds Ratio
Homozygote
Population

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dermaut, B., Croes, E. A., Rademakers, R. V., Van den Broeck, M. V., Cruts, M., Hofman, A., ... Van Broeckhoven, C. (2003). PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease. Annals of Neurology, 53(3), 409-412. https://doi.org/10.1002/ana.10507

PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease. / Dermaut, Bart; Croes, Esther A.; Rademakers, Rosa V; Van den Broeck, Marleen V.; Cruts, Marc; Hofman, Albert; Van Duijn, Cornelia M.; Van Broeckhoven, Christine.

In: Annals of Neurology, Vol. 53, No. 3, 01.03.2003, p. 409-412.

Research output: Contribution to journalArticle

Dermaut, B, Croes, EA, Rademakers, RV, Van den Broeck, MV, Cruts, M, Hofman, A, Van Duijn, CM & Van Broeckhoven, C 2003, 'PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease', Annals of Neurology, vol. 53, no. 3, pp. 409-412. https://doi.org/10.1002/ana.10507
Dermaut B, Croes EA, Rademakers RV, Van den Broeck MV, Cruts M, Hofman A et al. PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease. Annals of Neurology. 2003 Mar 1;53(3):409-412. https://doi.org/10.1002/ana.10507
Dermaut, Bart ; Croes, Esther A. ; Rademakers, Rosa V ; Van den Broeck, Marleen V. ; Cruts, Marc ; Hofman, Albert ; Van Duijn, Cornelia M. ; Van Broeckhoven, Christine. / PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease. In: Annals of Neurology. 2003 ; Vol. 53, No. 3. pp. 409-412.
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