PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease

Bart Dermaut, Esther A. Croes, Rosa Rademakers, Marleen V. Van den Broeck, Marc Cruts, Albert Hofman, Cornelia M. Van Duijn, Christine Van Broeckhoven

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

We analyzed the PRNP M129V polymorphism in a Dutch population-based early-onset Alzheimer's disease sample. We observed a significant association between early-onset Alzheimer's disease and homozygosity of M129V (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.1-3.3; p = 0.02) with the highest risk for V homozygotes (OR, 3.2; 95% CI, 1.4-7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3-5.3; p < 0.01) and 3.5 (95% CI, 1.3-9.3; p = 0.01), respectively.

Original languageEnglish (US)
Pages (from-to)409-412
Number of pages4
JournalAnnals of neurology
Volume53
Issue number3
DOIs
StatePublished - Mar 1 2003

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Dermaut, B., Croes, E. A., Rademakers, R., Van den Broeck, M. V., Cruts, M., Hofman, A., Van Duijn, C. M., & Van Broeckhoven, C. (2003). PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease. Annals of neurology, 53(3), 409-412. https://doi.org/10.1002/ana.10507