Priorities in colorectal cancer research: Recommendations from the Gastrointestinal Scientific Leadership Council of the Coalition of Cancer Cooperative Groups

Peter J. O'Dwyer, S. Gail Eckhardt, Daniel G. Haller, Joel Tepper, Dennis Ahnen, Stanley Hamilton, Al B. Benson, Mace Rothenberg, Nicholas Petrelli, Heinz Joseph Lenz, Robert B Diasio, Raymond DuBois, Daniel Sargent, Jeff A Sloan, C. Daniel Johnson, Robert L. Comis, Michael J. O'Connell

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Abstract

Emerging technologies have greatly expanded our ability to detect, characterize, and treat colorectal cancer. The Coalition of Cancer Cooperative Groups convened a multidisciplinary panel, the Scientific Leadership Council in GI cancer, to discuss and advise on the priorities and opportunities to advance current and future approaches into the clinical arena to impact most rapidly the morbidity and mortality from this disease. The Council's recommendations for research priorities are the result of engagement of community and academic oncologists, patient advocacy groups, and other stakeholders including the pharmaceutical industry and governmental agencies. We detail some key prospects for investigation in the areas of colon cancer detection, prevention, and surgical and medical management. Many are in early or definitive clinical trials, and a focus on rapid accrual is urged. The implementation of biology-directed laboratory investigations, both in association with ongoing clinical trials and as a separate developmental strategy for targeted therapies, is supported as the route to individualized therapy.

Original languageEnglish (US)
Pages (from-to)2313-2321
Number of pages9
JournalJournal of Clinical Oncology
Volume25
Issue number16
DOIs
StatePublished - Jun 1 2007

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

O'Dwyer, P. J., Eckhardt, S. G., Haller, D. G., Tepper, J., Ahnen, D., Hamilton, S., Benson, A. B., Rothenberg, M., Petrelli, N., Lenz, H. J., Diasio, R. B., DuBois, R., Sargent, D., Sloan, J. A., Johnson, C. D., Comis, R. L., & O'Connell, M. J. (2007). Priorities in colorectal cancer research: Recommendations from the Gastrointestinal Scientific Leadership Council of the Coalition of Cancer Cooperative Groups. Journal of Clinical Oncology, 25(16), 2313-2321. https://doi.org/10.1200/JCO.2006.08.6900