Prior image constrained compressed sensing (PICCS): A method to accurately reconstruct dynamic CT images from highly undersampled projection data sets

Guang Hong Chen, Jie Tang, Shuai Leng

Research output: Contribution to journalArticle

709 Scopus citations


When the number of projections does not satisfy the Shannon/Nyquist sampling requirement, streaking artifacts are inevitable in x-ray computed tomography (CT) images reconstructed using filtered backprojection algorithms. In this letter, the spatial-temporal correlations in dynamic CT imaging have been exploited to sparsify dynamic CT image sequences and the newly proposed compressed sensing (CS) reconstruction method is applied to reconstruct the target image sequences. A prior image reconstructed from the union of interleaved dynamical data sets is utilized to constrain the CS image reconstruction for the individual time frames. This method is referred to as prior image constrained compressed sensing (PICCS). In vivo experimental animal studies were conducted to validate the PICCS algorithm, and the results indicate that PICCS enables accurate reconstruction of dynamic CT images using about 20 view angles, which corresponds to an undersampling factor of 32. This undersampling factor implies a potential radiation dose reduction by a factor of 32 in myocardial CT perfusion imaging.

Original languageEnglish (US)
Pages (from-to)660-663
Number of pages4
JournalMedical physics
Issue number2
StatePublished - 2008



  • Compressed sensing
  • Dynamic CT
  • Image reconstruction

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

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