Abstract
During World War II, sailors who were accidentally exposed to nitrogen mustard following the explosion of a ship developed marrow and lymphoid hypoplasia. 1 This serendipitous discovery led to the first clinical trial conducted in 1942 using nitrogen mustard in patients with malignant lymphomas at Yale University.2 This marked the beginning of a new era of research in the quest for effective and safe drugs used in cancer chemotherapy.
Original language | English (US) |
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Title of host publication | Oncology |
Subtitle of host publication | An Evidence-Based Approach |
Publisher | Springer New York |
Pages | 14-40 |
Number of pages | 27 |
ISBN (Print) | 0387242910, 9780387242910 |
DOIs | |
State | Published - 2006 |
ASJC Scopus subject areas
- Medicine(all)