Primary signet ring cell carcinoma of the prostate

Jonathan N. Warner, Leah Y. Nakamura, Anna Pacelli, Mitchell R Humphreys, Erik P Castle

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Nine patients treated with primary signet ring cell carcinoma of the prostate were identified among 29,783 cases of prostate cancer evaluated at Mayo Clinic from January 15, 1970, until January 2, 2009. A PubMed search of the English-language literature published from January 1, 1980, to January 1, 2010, was then performed using the key words signet ring cell and prostate, identifying 42 cases. This study reviews those cases, along with the additional 9 reported herein, and evaluates clinical characteristics, histologic diagnoses, treatment modalities, and outcomes. Mean age at diagnosis was 68 years (range, 50-85 years), and mean prostate-specific antigen level was 95.3 ng/mL (range, 1.9-536.0 ng/mL; to convert to μg/L, multiply by 1). Most patients (66%) had non-stage IV carcinoma, the most common Gleason sum was 8 (33%), and mean survival was 29 months. The presence of a primary signet ring cell carcinoma of the prostate was best confirmed by negative findings on gastrointestinal work-up, a positive stain for prostate-specific acid phosphatase, and negative carcinoembryonic antigen test results.

Original languageEnglish (US)
Pages (from-to)1130-1136
Number of pages7
JournalMayo Clinic Proceedings
Volume85
Issue number12
DOIs
StatePublished - 2010

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Signet Ring Cell Carcinoma
Prostate
Carcinoembryonic Antigen
Prostate-Specific Antigen
Acid Phosphatase
PubMed
Prostatic Neoplasms
Coloring Agents
Language
Carcinoma
Survival

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Primary signet ring cell carcinoma of the prostate. / Warner, Jonathan N.; Nakamura, Leah Y.; Pacelli, Anna; Humphreys, Mitchell R; Castle, Erik P.

In: Mayo Clinic Proceedings, Vol. 85, No. 12, 2010, p. 1130-1136.

Research output: Contribution to journalArticle

Warner, Jonathan N. ; Nakamura, Leah Y. ; Pacelli, Anna ; Humphreys, Mitchell R ; Castle, Erik P. / Primary signet ring cell carcinoma of the prostate. In: Mayo Clinic Proceedings. 2010 ; Vol. 85, No. 12. pp. 1130-1136.
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