Abstract
Primary sclerosing cholangitis (PSC) is a chronic, idiopathic biliary tract disease characterized by segmental strictures. The disease is progressive with no proven treatments and may eventually lead to cirrhosis and end-stage liver disease. Abrupt changes in liver biochemistries, pain, and/or cholangitis may suggest a dominant stricture amenable to endoscopic therapy or the development of cholangiocarcinoma. Patients with PSC are at increased risk of cholangiocarcinoma. There is a strong association with inflammatory bowel disease, and an associated increased risk of colorectal cancer. Colonoscopy every 1 to 2 years is appropriate.
Original language | English (US) |
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Pages (from-to) | 725-737 |
Number of pages | 13 |
Journal | Clinics in liver disease |
Volume | 21 |
Issue number | 4 |
DOIs | |
State | Published - Nov 2017 |
Keywords
- Biliary tract disease
- Cholangiocarcinoma
- Cholestasis
- Inflammatory bowel disease
- Liver disease
- Primary sclerosing cholangitis
ASJC Scopus subject areas
- Hepatology