Primary Sclerosing Cholangitis: What the Gastroenterologist and Hepatologist Needs to Know

Andrea A. Gossard, Gregory J. Gores

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Primary sclerosing cholangitis (PSC) is a chronic, idiopathic biliary tract disease characterized by segmental strictures. The disease is progressive with no proven treatments and may eventually lead to cirrhosis and end-stage liver disease. Abrupt changes in liver biochemistries, pain, and/or cholangitis may suggest a dominant stricture amenable to endoscopic therapy or the development of cholangiocarcinoma. Patients with PSC are at increased risk of cholangiocarcinoma. There is a strong association with inflammatory bowel disease, and an associated increased risk of colorectal cancer. Colonoscopy every 1 to 2 years is appropriate.

Original languageEnglish (US)
Pages (from-to)725-737
Number of pages13
JournalClinics in liver disease
Volume21
Issue number4
DOIs
StatePublished - Nov 2017

Keywords

  • Biliary tract disease
  • Cholangiocarcinoma
  • Cholestasis
  • Inflammatory bowel disease
  • Liver disease
  • Primary sclerosing cholangitis

ASJC Scopus subject areas

  • Hepatology

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