Primary Sclerosing Cholangitis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Primary sclerosing cholangitis (PSC) is a progressive, cholestatic liver disease defined by diffuse inflammation and fibrosis of the bile ducts and is associated with inflammatory bowel disease. PSC leads to obliteration of the biliary tree and ultimately biliary cirrhosis. PSC has been diagnosed more frequently in the past three decades because of routine liver biochemistry testing in clinical practice and widespread availablility of endoscopic retrograde cholangiopancreatography and magnetic resonance cholangiopancreatography. To date, the etiology of PSC remains unknown and effective medical therapy is not currently available. Patients with PSC have shortened life expectancy due to disease progression and associated co-morbidities such as cholangiocarcinoma and colon cancer. Orthotopic liver transplantation extends the live of patients with advanced stage PSC.

Original languageEnglish (US)
Title of host publicationSchiff's Diseases of the Liver
PublisherWiley-Blackwell
Pages475-489
Number of pages15
ISBN (Print)0470654686, 9780470654682
DOIs
StatePublished - Oct 31 2011

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Keywords

  • Biliary epithelia
  • Cholangiocarcinoma
  • Cholestasis
  • Genetic predisposition
  • Inflammation
  • Liver transplantation
  • Pruritus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nguyen, D. L., Larusso, N. F., & Lazaridis, K. N. (2011). Primary Sclerosing Cholangitis. In Schiff's Diseases of the Liver (pp. 475-489). Wiley-Blackwell. https://doi.org/10.1002/9781119950509.ch20