Primary Sclerosing Cholangitis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Primary sclerosing cholangitis (PSC) is a progressive, cholestatic liver disease defined by diffuse inflammation and fibrosis of the bile ducts and is associated with inflammatory bowel disease. PSC leads to obliteration of the biliary tree and ultimately biliary cirrhosis. PSC has been diagnosed more frequently in the past three decades because of routine liver biochemistry testing in clinical practice and widespread availablility of endoscopic retrograde cholangiopancreatography and magnetic resonance cholangiopancreatography. To date, the etiology of PSC remains unknown and effective medical therapy is not currently available. Patients with PSC have shortened life expectancy due to disease progression and associated co-morbidities such as cholangiocarcinoma and colon cancer. Orthotopic liver transplantation extends the live of patients with advanced stage PSC.

Original languageEnglish (US)
Title of host publicationSchiff's Diseases of the Liver
PublisherWiley-Blackwell
Pages475-489
Number of pages15
ISBN (Print)0470654686, 9780470654682
DOIs
StatePublished - Oct 31 2011

Fingerprint

Sclerosing Cholangitis
Magnetic Resonance Cholangiopancreatography
Cholangiocarcinoma
Biliary Liver Cirrhosis
Endoscopic Retrograde Cholangiopancreatography
Biliary Tract
Life Expectancy
Bile Ducts
Inflammatory Bowel Diseases
Biochemistry
Liver Transplantation
Colonic Neoplasms
Disease Progression
Liver Diseases
Fibrosis
Inflammation
Morbidity
Liver

Keywords

  • Biliary epithelia
  • Cholangiocarcinoma
  • Cholestasis
  • Genetic predisposition
  • Inflammation
  • Liver transplantation
  • Pruritus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nguyen, D. L., La Russo, N. F., & Lazaridis, K. N. (2011). Primary Sclerosing Cholangitis. In Schiff's Diseases of the Liver (pp. 475-489). Wiley-Blackwell. https://doi.org/10.1002/9781119950509.ch20

Primary Sclerosing Cholangitis. / Nguyen, Douglas L.; La Russo, Nicholas F; Lazaridis, Konstantinos N.

Schiff's Diseases of the Liver. Wiley-Blackwell, 2011. p. 475-489.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nguyen, DL, La Russo, NF & Lazaridis, KN 2011, Primary Sclerosing Cholangitis. in Schiff's Diseases of the Liver. Wiley-Blackwell, pp. 475-489. https://doi.org/10.1002/9781119950509.ch20
Nguyen DL, La Russo NF, Lazaridis KN. Primary Sclerosing Cholangitis. In Schiff's Diseases of the Liver. Wiley-Blackwell. 2011. p. 475-489 https://doi.org/10.1002/9781119950509.ch20
Nguyen, Douglas L. ; La Russo, Nicholas F ; Lazaridis, Konstantinos N. / Primary Sclerosing Cholangitis. Schiff's Diseases of the Liver. Wiley-Blackwell, 2011. pp. 475-489
@inbook{0dd873f58c27472ea9f4eabb2de0a001,
title = "Primary Sclerosing Cholangitis",
abstract = "Primary sclerosing cholangitis (PSC) is a progressive, cholestatic liver disease defined by diffuse inflammation and fibrosis of the bile ducts and is associated with inflammatory bowel disease. PSC leads to obliteration of the biliary tree and ultimately biliary cirrhosis. PSC has been diagnosed more frequently in the past three decades because of routine liver biochemistry testing in clinical practice and widespread availablility of endoscopic retrograde cholangiopancreatography and magnetic resonance cholangiopancreatography. To date, the etiology of PSC remains unknown and effective medical therapy is not currently available. Patients with PSC have shortened life expectancy due to disease progression and associated co-morbidities such as cholangiocarcinoma and colon cancer. Orthotopic liver transplantation extends the live of patients with advanced stage PSC.",
keywords = "Biliary epithelia, Cholangiocarcinoma, Cholestasis, Genetic predisposition, Inflammation, Liver transplantation, Pruritus",
author = "Nguyen, {Douglas L.} and {La Russo}, {Nicholas F} and Lazaridis, {Konstantinos N}",
year = "2011",
month = "10",
day = "31",
doi = "10.1002/9781119950509.ch20",
language = "English (US)",
isbn = "0470654686",
pages = "475--489",
booktitle = "Schiff's Diseases of the Liver",
publisher = "Wiley-Blackwell",

}

TY - CHAP

T1 - Primary Sclerosing Cholangitis

AU - Nguyen, Douglas L.

AU - La Russo, Nicholas F

AU - Lazaridis, Konstantinos N

PY - 2011/10/31

Y1 - 2011/10/31

N2 - Primary sclerosing cholangitis (PSC) is a progressive, cholestatic liver disease defined by diffuse inflammation and fibrosis of the bile ducts and is associated with inflammatory bowel disease. PSC leads to obliteration of the biliary tree and ultimately biliary cirrhosis. PSC has been diagnosed more frequently in the past three decades because of routine liver biochemistry testing in clinical practice and widespread availablility of endoscopic retrograde cholangiopancreatography and magnetic resonance cholangiopancreatography. To date, the etiology of PSC remains unknown and effective medical therapy is not currently available. Patients with PSC have shortened life expectancy due to disease progression and associated co-morbidities such as cholangiocarcinoma and colon cancer. Orthotopic liver transplantation extends the live of patients with advanced stage PSC.

AB - Primary sclerosing cholangitis (PSC) is a progressive, cholestatic liver disease defined by diffuse inflammation and fibrosis of the bile ducts and is associated with inflammatory bowel disease. PSC leads to obliteration of the biliary tree and ultimately biliary cirrhosis. PSC has been diagnosed more frequently in the past three decades because of routine liver biochemistry testing in clinical practice and widespread availablility of endoscopic retrograde cholangiopancreatography and magnetic resonance cholangiopancreatography. To date, the etiology of PSC remains unknown and effective medical therapy is not currently available. Patients with PSC have shortened life expectancy due to disease progression and associated co-morbidities such as cholangiocarcinoma and colon cancer. Orthotopic liver transplantation extends the live of patients with advanced stage PSC.

KW - Biliary epithelia

KW - Cholangiocarcinoma

KW - Cholestasis

KW - Genetic predisposition

KW - Inflammation

KW - Liver transplantation

KW - Pruritus

UR - http://www.scopus.com/inward/record.url?scp=84886571890&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886571890&partnerID=8YFLogxK

U2 - 10.1002/9781119950509.ch20

DO - 10.1002/9781119950509.ch20

M3 - Chapter

AN - SCOPUS:84886571890

SN - 0470654686

SN - 9780470654682

SP - 475

EP - 489

BT - Schiff's Diseases of the Liver

PB - Wiley-Blackwell

ER -