Primary peripheral PNET/Ewing's sarcoma of the dura: A clinicopathologic entity distinct from central PNET

Franceska Dedeurwaerdere, Caterina Giannini, Raf Sciot, Brian P. Rubin, Giorgio Perilongo, Laura Borghi, Maria Luisa Ballotta, Erwin Cornips, Anouk Demunter, Brigitte Maes, Angelo P. Dei Tos

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73 Scopus citations

Abstract

We describe two cases of peripheral primitive neuroectodermal tumor-Ewing's sarcoma (PNET-ES) arising intracranially in the leptomeninges. Both tumors exhibited a primitive undifferentiated round-cell morphology. Immunohistochemical stains revealed strong membrane expression of CD99 in both cases. A t(11;22)(q24;q12) could be demonstrated with reverse transcriptase-polymerase chain reaction in one case, whereas fluorescence in situ hybridization analysis performed in the second case showed a rearrangement of the EWS gene. The occurrence of PNET-ES at this site is very unusual. Immunophenotypical as well as genetic analysis play a key role in the diagnosis and the distinction from central PNET.

Original languageEnglish (US)
Pages (from-to)673-678
Number of pages6
JournalModern Pathology
Volume15
Issue number6
DOIs
StatePublished - Jan 1 2002

Keywords

  • CD99
  • Ewing's sarcoma
  • Meninges
  • Peripheral primitive neuroectodermal tumor
  • T(11;22)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Dedeurwaerdere, F., Giannini, C., Sciot, R., Rubin, B. P., Perilongo, G., Borghi, L., Ballotta, M. L., Cornips, E., Demunter, A., Maes, B., & Dei Tos, A. P. (2002). Primary peripheral PNET/Ewing's sarcoma of the dura: A clinicopathologic entity distinct from central PNET. Modern Pathology, 15(6), 673-678. https://doi.org/10.1038/modpathol.3880585