Primary peripheral PNET/Ewing's sarcoma of the dura: A clinicopathologic entity distinct from central PNET

Franceska Dedeurwaerdere; Caterina Giannini; Raf Sciot; Brian P. Rubin; Giorgio Perilongo; Laura Borghi; Maria Luisa Ballotta; Erwin Cornips; Anouk Demunter; Brigitte Maes; Angelo P. Dei Tos

doi:10.1038/modpathol.3880585

Primary peripheral PNET/Ewing's sarcoma of the dura: A clinicopathologic entity distinct from central PNET

Franceska Dedeurwaerdere, Caterina Giannini, Raf Sciot, Brian P. Rubin, Giorgio Perilongo, Laura Borghi, Maria Luisa Ballotta, Erwin Cornips, Anouk Demunter, Brigitte Maes, Angelo P. Dei Tos

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

We describe two cases of peripheral primitive neuroectodermal tumor-Ewing's sarcoma (PNET-ES) arising intracranially in the leptomeninges. Both tumors exhibited a primitive undifferentiated round-cell morphology. Immunohistochemical stains revealed strong membrane expression of CD99 in both cases. A t(11;22)(q24;q12) could be demonstrated with reverse transcriptase-polymerase chain reaction in one case, whereas fluorescence in situ hybridization analysis performed in the second case showed a rearrangement of the EWS gene. The occurrence of PNET-ES at this site is very unusual. Immunophenotypical as well as genetic analysis play a key role in the diagnosis and the distinction from central PNET.

Original language	English (US)
Pages (from-to)	673-678
Number of pages	6
Journal	Modern Pathology
Volume	15
Issue number	6
DOIs	https://doi.org/10.1038/modpathol.3880585
State	Published - 2002

Keywords

CD99
Ewing's sarcoma
Meninges
Peripheral primitive neuroectodermal tumor
T(11;22)

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1038/modpathol.3880585

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title = "Primary peripheral PNET/Ewing's sarcoma of the dura: A clinicopathologic entity distinct from central PNET",

abstract = "We describe two cases of peripheral primitive neuroectodermal tumor-Ewing's sarcoma (PNET-ES) arising intracranially in the leptomeninges. Both tumors exhibited a primitive undifferentiated round-cell morphology. Immunohistochemical stains revealed strong membrane expression of CD99 in both cases. A t(11;22)(q24;q12) could be demonstrated with reverse transcriptase-polymerase chain reaction in one case, whereas fluorescence in situ hybridization analysis performed in the second case showed a rearrangement of the EWS gene. The occurrence of PNET-ES at this site is very unusual. Immunophenotypical as well as genetic analysis play a key role in the diagnosis and the distinction from central PNET.",

keywords = "CD99, Ewing's sarcoma, Meninges, Peripheral primitive neuroectodermal tumor, T(11;22)",

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T2 - A clinicopathologic entity distinct from central PNET

AU - Dedeurwaerdere, Franceska

AU - Giannini, Caterina

AU - Sciot, Raf

AU - Rubin, Brian P.

AU - Perilongo, Giorgio

AU - Borghi, Laura

AU - Ballotta, Maria Luisa

AU - Cornips, Erwin

AU - Demunter, Anouk

AU - Maes, Brigitte

AU - Dei Tos, Angelo P.

PY - 2002

Y1 - 2002

N2 - We describe two cases of peripheral primitive neuroectodermal tumor-Ewing's sarcoma (PNET-ES) arising intracranially in the leptomeninges. Both tumors exhibited a primitive undifferentiated round-cell morphology. Immunohistochemical stains revealed strong membrane expression of CD99 in both cases. A t(11;22)(q24;q12) could be demonstrated with reverse transcriptase-polymerase chain reaction in one case, whereas fluorescence in situ hybridization analysis performed in the second case showed a rearrangement of the EWS gene. The occurrence of PNET-ES at this site is very unusual. Immunophenotypical as well as genetic analysis play a key role in the diagnosis and the distinction from central PNET.

AB - We describe two cases of peripheral primitive neuroectodermal tumor-Ewing's sarcoma (PNET-ES) arising intracranially in the leptomeninges. Both tumors exhibited a primitive undifferentiated round-cell morphology. Immunohistochemical stains revealed strong membrane expression of CD99 in both cases. A t(11;22)(q24;q12) could be demonstrated with reverse transcriptase-polymerase chain reaction in one case, whereas fluorescence in situ hybridization analysis performed in the second case showed a rearrangement of the EWS gene. The occurrence of PNET-ES at this site is very unusual. Immunophenotypical as well as genetic analysis play a key role in the diagnosis and the distinction from central PNET.

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KW - Ewing's sarcoma

KW - Meninges

KW - Peripheral primitive neuroectodermal tumor

KW - T(11;22)

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Primary peripheral PNET/Ewing's sarcoma of the dura: A clinicopathologic entity distinct from central PNET

Abstract

Keywords

ASJC Scopus subject areas

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