Primary neuroendocrine carcinoma of the brain

Clay T. Reed, Narjust Duma, Thorvardur Halfdanarson, Jan Buckner

Research output: Contribution to journalArticle

Abstract

Neuroendocrine neoplasms (NENs) are malignancies with rare reports of central nervous system development. A 34-year-old woman was found to have a primary NEN of the brain, and she had recurrence with identical histology 10 years later. Extracranial NENs were excluded. She had routine surveillance for the first 5 years with MRIs and positron emission tomography/CTs after the initial presentation which was treated with radiation followed by cisplatin and etoposide. This case highlights the difference in primary NENs versus NEN metastases to the brain, and that longer periods of surveillance are likely required for primary NENs. This is important because the prognosis between primary NENs and metastatic NENs to the brain are vastly different and should not be treated as equal diseases. The patient eventually died of her recurrence secondary to complications of a ventriculoperitoneal shunt placed for treatment of hydrocephalus from the disease.

Original languageEnglish (US)
Article numbere230582
JournalBMJ case reports
Volume12
Issue number9
DOIs
StatePublished - Sep 1 2019

Keywords

  • CNS Cancer
  • neuroendocrinology
  • neurooncology

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Reed, C. T., Duma, N., Halfdanarson, T., & Buckner, J. (2019). Primary neuroendocrine carcinoma of the brain. BMJ case reports, 12(9), [e230582]. https://doi.org/10.1136/bcr-2019-230582