Primary neuroblastoma of the maxillary sinus

Julie L. Wei, Bernd W. Scheithauer, Justin S. Smith, Robert Brian Jenkins, Sandra M. Passe, Carola A.S. Arndt, Scott E. Strome

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Although neuroblastoma is the most common of extracranial solid tumors of childhood and infancy, we report the first case of an isolated neuroblastoma of a paranasal sinus. A 15-year-old girl with a right maxillary sinus mass was asymptomatic except for persistent epiphora. Computed tomography and magnetic resonance imaging scans showed that the mass extended into the nasal cavity, encroached on the lamina papyracea, and obstructed the nasofrontal duct. An extensive workup revealed no evidence of systemic disease. The patient underwent right craniofacial resection. Immunohistochemistry and electronmicroscopic findings were consistent with conventional neuroblastoma. Fluorescence in situ hybridization analysis was performed with probes selected to demonstrate genetic alterations associated with neuroblastoma. Studies revealed deletion of chromosome arm 1p, gain of chromosome 17, and normal N-myc gene copy number. In summary, the tumor exhibited morphologic features and genetic alterations more consistent with those of neuroblastoma than with those of esthesioneuroblastoma.

Original languageEnglish (US)
Pages (from-to)155-162
Number of pages8
JournalInternational Journal of Pediatric Otorhinolaryngology
Volume63
Issue number2
DOIs
StatePublished - Apr 25 2002

Fingerprint

Maxillary Sinus
Neuroblastoma
Olfactory Esthesioneuroblastoma
Lacrimal Apparatus Diseases
Chromosome Deletion
Chromosomes, Human, Pair 17
myc Genes
Gene Dosage
Paranasal Sinuses
Nasal Cavity
Patient Rights
Fluorescence In Situ Hybridization
Neoplasms
Arm
Immunohistochemistry
Tomography
Magnetic Resonance Imaging

Keywords

  • Craniofacial resection
  • Esthesioneuroblastoma
  • Fluorescence in situ hybridization
  • Maxillary sinus
  • N-myc gene amplification
  • Neuroblastoma

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Primary neuroblastoma of the maxillary sinus. / Wei, Julie L.; Scheithauer, Bernd W.; Smith, Justin S.; Jenkins, Robert Brian; Passe, Sandra M.; Arndt, Carola A.S.; Strome, Scott E.

In: International Journal of Pediatric Otorhinolaryngology, Vol. 63, No. 2, 25.04.2002, p. 155-162.

Research output: Contribution to journalArticle

Wei, Julie L. ; Scheithauer, Bernd W. ; Smith, Justin S. ; Jenkins, Robert Brian ; Passe, Sandra M. ; Arndt, Carola A.S. ; Strome, Scott E. / Primary neuroblastoma of the maxillary sinus. In: International Journal of Pediatric Otorhinolaryngology. 2002 ; Vol. 63, No. 2. pp. 155-162.
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