Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post-ET MF), blast phase PMF (PMF-BP)

Consensus on terminology by the international working group for myelofibrosis research and treatment (IWG-MRT)

Ruben A. Mesa, Srdan Verstovsek, Francisco Cervantes, Giovanni Barosi, John T. Reilly, Brigitte Dupriez, Ross Levine, Marie Caroline Le Bousse-Kerdiles, Martha Wadleigh, Peter J. Campbell, Richard T. Silver, Alessandro M. Vannucchi, H. Joachim Deeg, Heinz Gisslinger, Deborah Thomas, Olatoyosi Odenike, Lawrence A. Solberg, Jason Gotlib, Elizabeth Hexner, Stephen D. Nimer & 5 others Hagop Kantarjian, Attilio Orazi, James W. Vardiman, Juergen Thiele, Ayalew Tefferi

Research output: Contribution to journalArticle

193 Citations (Scopus)

Abstract

The International Working Group for Myelofibrosis Research and Treatment (IWG-MRT) is comprised of hematologists, hematopathologists, and laboratory scientists and its main goal is to provide a forum for scientific exchange and collaboration. During its first general meeting in April 2006, the IWG-MRT established uniform treatment response criteria for chronic idiopathic myelofibrosis (CIMF); also known as agnogenic myeloid metaplasia (AMM), myelofibrosis with myeloid metaplasia (MMM), and many other names in the hematologic literature. This document summarizes the proceedings from the second meeting of the IWG-MRT, in November 2006, where the group discussed and agreed to standardize the nomenclature referring to CIMF: (i) the term primary myelofibrosis (PMF) was chosen over several other designations including CIMF, AMM, and MMM, (ii) myelofibrosis that develops in the setting of either polycythemia vera (PV) or essential thrombocythemia (ET) will be referred to as post-PV MF and post-ET MF, respectively, and (iii) "leukemic" transformation will be recognized as blast phase disease (PMF-BP, post-PV/ET MF in blast phase).

Original languageEnglish (US)
Pages (from-to)737-740
Number of pages4
JournalLeukemia Research
Volume31
Issue number6
DOIs
StatePublished - Jun 2007

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Blast Crisis
Essential Thrombocythemia
Polycythemia Vera
Primary Myelofibrosis
Terminology
Research
Therapeutics
Laboratory Personnel

Keywords

  • Chronic idiopathic myelofibrosis
  • International Working Group for Myelofibrosis Research and Treatment
  • IWG-MRT
  • Myelofibrosis
  • Myelofibrosis with myeloid metaplasia
  • Myeloproliferative disorders
  • Primary myelofibrosis

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post-ET MF), blast phase PMF (PMF-BP) : Consensus on terminology by the international working group for myelofibrosis research and treatment (IWG-MRT). / Mesa, Ruben A.; Verstovsek, Srdan; Cervantes, Francisco; Barosi, Giovanni; Reilly, John T.; Dupriez, Brigitte; Levine, Ross; Le Bousse-Kerdiles, Marie Caroline; Wadleigh, Martha; Campbell, Peter J.; Silver, Richard T.; Vannucchi, Alessandro M.; Deeg, H. Joachim; Gisslinger, Heinz; Thomas, Deborah; Odenike, Olatoyosi; Solberg, Lawrence A.; Gotlib, Jason; Hexner, Elizabeth; Nimer, Stephen D.; Kantarjian, Hagop; Orazi, Attilio; Vardiman, James W.; Thiele, Juergen; Tefferi, Ayalew.

In: Leukemia Research, Vol. 31, No. 6, 06.2007, p. 737-740.

Research output: Contribution to journalArticle

Mesa, RA, Verstovsek, S, Cervantes, F, Barosi, G, Reilly, JT, Dupriez, B, Levine, R, Le Bousse-Kerdiles, MC, Wadleigh, M, Campbell, PJ, Silver, RT, Vannucchi, AM, Deeg, HJ, Gisslinger, H, Thomas, D, Odenike, O, Solberg, LA, Gotlib, J, Hexner, E, Nimer, SD, Kantarjian, H, Orazi, A, Vardiman, JW, Thiele, J & Tefferi, A 2007, 'Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post-ET MF), blast phase PMF (PMF-BP): Consensus on terminology by the international working group for myelofibrosis research and treatment (IWG-MRT)', Leukemia Research, vol. 31, no. 6, pp. 737-740. https://doi.org/10.1016/j.leukres.2006.12.002
Mesa, Ruben A. ; Verstovsek, Srdan ; Cervantes, Francisco ; Barosi, Giovanni ; Reilly, John T. ; Dupriez, Brigitte ; Levine, Ross ; Le Bousse-Kerdiles, Marie Caroline ; Wadleigh, Martha ; Campbell, Peter J. ; Silver, Richard T. ; Vannucchi, Alessandro M. ; Deeg, H. Joachim ; Gisslinger, Heinz ; Thomas, Deborah ; Odenike, Olatoyosi ; Solberg, Lawrence A. ; Gotlib, Jason ; Hexner, Elizabeth ; Nimer, Stephen D. ; Kantarjian, Hagop ; Orazi, Attilio ; Vardiman, James W. ; Thiele, Juergen ; Tefferi, Ayalew. / Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post-ET MF), blast phase PMF (PMF-BP) : Consensus on terminology by the international working group for myelofibrosis research and treatment (IWG-MRT). In: Leukemia Research. 2007 ; Vol. 31, No. 6. pp. 737-740.
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