Primary myelofi brosis

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Myelofibrosis (MF) in the context of a myeloproliferative disorder is a clinicopathologically defined entity characterized by anemia, marked splenomegaly, constitutional symptoms, leukoerythroblastosis (i.e., the presence of immature granulocytes and nucleated red blood cells), dacryocytosis (i.e., presence of teardrop-shaped red blood cells), and a bone marrow that displays dysplastic megakaryocyte hyperplasia, granulocyte proliferation, and reticulin and/or collagen fibrosis (1). Disease presentation could be either de novo (primary MF; PMF) or preceded by either polycythemia vera (post-PV MF) or essential thrombocythemia (post-ET MF). PMF is also known by many other names (Table 2.1), including chronic idiopathic myelofibrosis (CIMF), the term used by the World Health Organization (WHO) system for classification of myeloid neoplasms (2). However, the use of the term PMF was recently endorsed by the International Working Group for Myelofibrosis Research and Treatment (IWG-MRT) (3).

Original languageEnglish (US)
Title of host publicationRare Hematological Malignancies
PublisherSpringer US
Pages29-49
Number of pages21
ISBN (Print)9780387737430
DOIs
StatePublished - Dec 1 2008

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tefferi, A. (2008). Primary myelofi brosis. In Rare Hematological Malignancies (pp. 29-49). Springer US. https://doi.org/10.1007/978-0-387-73744-7_2