Primary myelodysplastic syndrome with normal cytogenetics: Utility of ‘FISH panel testing’ and M-FISH

Rhett P. Ketterling; William A. Wyatt; Scott A. VanWier; Mark Law; Janice M. Hodnefield; Curtis A. Hanson; Gordon W. Dewald

doi:10.1016/S0145-2126(01)00117-5

Primary myelodysplastic syndrome with normal cytogenetics: Utility of ‘FISH panel testing’ and M-FISH

Rhett P. Ketterling, William A. Wyatt, Scott A. VanWier, Mark Law, Janice M. Hodnefield, Curtis A. Hanson, Gordon W. Dewald

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

The myelodysplastic syndromes (MDS) are a clinically heterogeneous group of hematologic disorders. Cytogenetic analysis is crucial as it can provide both diagnostic and prognostic information. Herein, 32 cytogenetically normal patients with primary MDS were analyzed both by multiple FISH probes on interphase nuclei (FISH panel testing) and by M-FISH (metaphase nuclei). One patient had a chromosome 13q-arm deletion, while the remaining 31 patients had normal results. These findings confirm standard cytogenetics as an excellent technique in identifying the common chromosomal abnormalities associated with MDS and suggest limited utility for either a FISH panel test or M-FISH in primary MDS.

Original language	English (US)
Pages (from-to)	235-240
Number of pages	6
Journal	Leukemia Research
Volume	26
Issue number	3
DOIs	https://doi.org/10.1016/S0145-2126(01)00117-5
State	Published - 2002

Keywords

Chromosome
Cytogenetics
FISH
Hematology
M-FISH
Myelodysplastic syndrome

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/S0145-2126(01)00117-5

Cite this

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title = "Primary myelodysplastic syndrome with normal cytogenetics: Utility of {\textquoteleft}FISH panel testing{\textquoteright} and M-FISH",

abstract = "The myelodysplastic syndromes (MDS) are a clinically heterogeneous group of hematologic disorders. Cytogenetic analysis is crucial as it can provide both diagnostic and prognostic information. Herein, 32 cytogenetically normal patients with primary MDS were analyzed both by multiple FISH probes on interphase nuclei (FISH panel testing) and by M-FISH (metaphase nuclei). One patient had a chromosome 13q-arm deletion, while the remaining 31 patients had normal results. These findings confirm standard cytogenetics as an excellent technique in identifying the common chromosomal abnormalities associated with MDS and suggest limited utility for either a FISH panel test or M-FISH in primary MDS.",

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T1 - Primary myelodysplastic syndrome with normal cytogenetics

T2 - Utility of ‘FISH panel testing’ and M-FISH

AU - Ketterling, Rhett P.

AU - Wyatt, William A.

AU - VanWier, Scott A.

AU - Law, Mark

AU - Hodnefield, Janice M.

AU - Hanson, Curtis A.

AU - Dewald, Gordon W.

PY - 2002

Y1 - 2002

N2 - The myelodysplastic syndromes (MDS) are a clinically heterogeneous group of hematologic disorders. Cytogenetic analysis is crucial as it can provide both diagnostic and prognostic information. Herein, 32 cytogenetically normal patients with primary MDS were analyzed both by multiple FISH probes on interphase nuclei (FISH panel testing) and by M-FISH (metaphase nuclei). One patient had a chromosome 13q-arm deletion, while the remaining 31 patients had normal results. These findings confirm standard cytogenetics as an excellent technique in identifying the common chromosomal abnormalities associated with MDS and suggest limited utility for either a FISH panel test or M-FISH in primary MDS.

AB - The myelodysplastic syndromes (MDS) are a clinically heterogeneous group of hematologic disorders. Cytogenetic analysis is crucial as it can provide both diagnostic and prognostic information. Herein, 32 cytogenetically normal patients with primary MDS were analyzed both by multiple FISH probes on interphase nuclei (FISH panel testing) and by M-FISH (metaphase nuclei). One patient had a chromosome 13q-arm deletion, while the remaining 31 patients had normal results. These findings confirm standard cytogenetics as an excellent technique in identifying the common chromosomal abnormalities associated with MDS and suggest limited utility for either a FISH panel test or M-FISH in primary MDS.

KW - Chromosome

KW - Cytogenetics

KW - FISH

KW - Hematology

KW - M-FISH

KW - Myelodysplastic syndrome

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Primary myelodysplastic syndrome with normal cytogenetics: Utility of ‘FISH panel testing’ and M-FISH

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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