Primary mucinous carcinoma of the skin: The mayo clinic experience over the past 2 decades

Jessica A. Adefusika, Jason D. Pimentel, Rahul N. Chavan, Jerry D. Brewer

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

BACKGROUND: Primary mucinous carcinoma of the skin (PMCS) is a rare adnexal eccrine sweat gland neoplasm, often mistaken for metastasis from extracutaneous sites or misdiagnosed. Primary mucinous carcinoma of the skin is a slow-growing tumor with a high recurrence rate after conventional excision. OBJECTIVE: To describe clinicopathologic features, rate of recurrence, and metastasis and to review relevant literature. MATERIALS AND METHODS: The authors identified patients with PMCS treated from January 1992 through December 2012 at Mayo Clinic. The authors retrospectively reviewed medical records and histology slides. Relevant publications were identified through Ovid MEDLINE and PubMed. RESULTS: Six patients with PMCS were identified (1 male). The average age at diagnosis was 63 years. Tumor size ranged from 0.5 to 2.0 cm, and all were confined within the dermis. No evidence of metastatic mucinous adenocarcinoma was documented at the time of diagnosis. Five patients underwent Mohs micrographic surgery, and 1 was treated with wide local excision. There were no episodes of recurrence or metastases after a median follow-up of 20 months (range, 0.5-207 months). CONCLUSION: Mohs micrographic surgery may offer reduced recurrence rates and better outcomes in PMCS. Further studies with longer follow-up and bigger cohorts of patients with PMCS are warranted.

Original languageEnglish (US)
Pages (from-to)201-208
Number of pages8
JournalDermatologic Surgery
Volume41
Issue number2
DOIs
StatePublished - Feb 13 2015

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Mucinous Adenocarcinoma
Skin
Mohs Surgery
Recurrence
Neoplasm Metastasis
Sweat Gland Neoplasms
Eccrine Glands
Dermis
Diagnostic Errors
PubMed
MEDLINE
Medical Records
Publications
Neoplasms
Histology

ASJC Scopus subject areas

  • Dermatology
  • Surgery

Cite this

Primary mucinous carcinoma of the skin : The mayo clinic experience over the past 2 decades. / Adefusika, Jessica A.; Pimentel, Jason D.; Chavan, Rahul N.; Brewer, Jerry D.

In: Dermatologic Surgery, Vol. 41, No. 2, 13.02.2015, p. 201-208.

Research output: Contribution to journalArticle

Adefusika, Jessica A. ; Pimentel, Jason D. ; Chavan, Rahul N. ; Brewer, Jerry D. / Primary mucinous carcinoma of the skin : The mayo clinic experience over the past 2 decades. In: Dermatologic Surgery. 2015 ; Vol. 41, No. 2. pp. 201-208.
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