Primary mediastinal large B-cell lymphoma in HIV: Report of two cases

Katalin Kelemen; Wendy Cao; Lo Ann C. Peterson; Andrew M. Evens; Daina Variakojis

doi:10.1007/s12308-009-0022-3

Primary mediastinal large B-cell lymphoma in HIV: Report of two cases

Katalin Kelemen, Wendy Cao, Lo Ann C. Peterson, Andrew M. Evens, Daina Variakojis

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Primary mediastinal large B cell lymphoma (PMLBCL) is a subtype of diffuse large B cell lymphoma arising in the mediastinum with distinctive clinical and morphological features. Though diffuse large B cell lymphoma is one of the most common non-Hodgkin lymphoma associated with AIDS, there are no data available regarding the association of HIV and PMLBCL. We report here two cases of PMLBCL arising in AIDS patients. In both cases, PMLBCL presented in a setting of low CD4 T-cell count as rapidly enlarging mediastinal mass. The morphologic and immunophenotypic findings are characteristic of PMLBCL. One of the two patients, a 25-year-old woman who had localized disease and evidence of Epstein-Barr virus in lymphoma cells, did not respond to chemotherapy and died of disease progression 5 months after diagnosis. The second patient, a 38-year-old male with disseminated disease, responded to therapy and is diseasefree after 9 months of follow-up.

Original language	English (US)
Pages (from-to)	45-49
Number of pages	5
Journal	Journal of Hematopathology
Volume	2
Issue number	1
DOIs	https://doi.org/10.1007/s12308-009-0022-3
State	Published - 2009

Keywords

EBV
HIV
Primary Mediastinal Large B Cell Lymphoma

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology
Hematology

Access to Document

10.1007/s12308-009-0022-3

Cite this

@article{120f65015949469f8023af7d1c4eb847,

title = "Primary mediastinal large B-cell lymphoma in HIV: Report of two cases",

abstract = "Primary mediastinal large B cell lymphoma (PMLBCL) is a subtype of diffuse large B cell lymphoma arising in the mediastinum with distinctive clinical and morphological features. Though diffuse large B cell lymphoma is one of the most common non-Hodgkin lymphoma associated with AIDS, there are no data available regarding the association of HIV and PMLBCL. We report here two cases of PMLBCL arising in AIDS patients. In both cases, PMLBCL presented in a setting of low CD4 T-cell count as rapidly enlarging mediastinal mass. The morphologic and immunophenotypic findings are characteristic of PMLBCL. One of the two patients, a 25-year-old woman who had localized disease and evidence of Epstein-Barr virus in lymphoma cells, did not respond to chemotherapy and died of disease progression 5 months after diagnosis. The second patient, a 38-year-old male with disseminated disease, responded to therapy and is diseasefree after 9 months of follow-up.",

keywords = "EBV, HIV, Primary Mediastinal Large B Cell Lymphoma",

author = "Katalin Kelemen and Wendy Cao and Peterson, {Lo Ann C.} and Evens, {Andrew M.} and Daina Variakojis",

year = "2009",

doi = "10.1007/s12308-009-0022-3",

language = "English (US)",

volume = "2",

pages = "45--49",

journal = "Journal of Hematopathology",

issn = "1865-5785",

publisher = "Springer Verlag",

number = "1",

}

TY - JOUR

T1 - Primary mediastinal large B-cell lymphoma in HIV

T2 - Report of two cases

AU - Kelemen, Katalin

AU - Cao, Wendy

AU - Peterson, Lo Ann C.

AU - Evens, Andrew M.

AU - Variakojis, Daina

PY - 2009

Y1 - 2009

N2 - Primary mediastinal large B cell lymphoma (PMLBCL) is a subtype of diffuse large B cell lymphoma arising in the mediastinum with distinctive clinical and morphological features. Though diffuse large B cell lymphoma is one of the most common non-Hodgkin lymphoma associated with AIDS, there are no data available regarding the association of HIV and PMLBCL. We report here two cases of PMLBCL arising in AIDS patients. In both cases, PMLBCL presented in a setting of low CD4 T-cell count as rapidly enlarging mediastinal mass. The morphologic and immunophenotypic findings are characteristic of PMLBCL. One of the two patients, a 25-year-old woman who had localized disease and evidence of Epstein-Barr virus in lymphoma cells, did not respond to chemotherapy and died of disease progression 5 months after diagnosis. The second patient, a 38-year-old male with disseminated disease, responded to therapy and is diseasefree after 9 months of follow-up.

AB - Primary mediastinal large B cell lymphoma (PMLBCL) is a subtype of diffuse large B cell lymphoma arising in the mediastinum with distinctive clinical and morphological features. Though diffuse large B cell lymphoma is one of the most common non-Hodgkin lymphoma associated with AIDS, there are no data available regarding the association of HIV and PMLBCL. We report here two cases of PMLBCL arising in AIDS patients. In both cases, PMLBCL presented in a setting of low CD4 T-cell count as rapidly enlarging mediastinal mass. The morphologic and immunophenotypic findings are characteristic of PMLBCL. One of the two patients, a 25-year-old woman who had localized disease and evidence of Epstein-Barr virus in lymphoma cells, did not respond to chemotherapy and died of disease progression 5 months after diagnosis. The second patient, a 38-year-old male with disseminated disease, responded to therapy and is diseasefree after 9 months of follow-up.

KW - EBV

KW - HIV

KW - Primary Mediastinal Large B Cell Lymphoma

UR - http://www.scopus.com/inward/record.url?scp=84880575594&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880575594&partnerID=8YFLogxK

U2 - 10.1007/s12308-009-0022-3

DO - 10.1007/s12308-009-0022-3

M3 - Article

C2 - 19669223

AN - SCOPUS:84880575594

SN - 1865-5785

VL - 2

SP - 45

EP - 49

JO - Journal of Hematopathology

JF - Journal of Hematopathology

IS - 1

ER -

Primary mediastinal large B-cell lymphoma in HIV: Report of two cases

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this