Primary malignant ependymoma of the lung

T. B. Crotty, R. P. Hooker, S. J. Swensen, B. W. Scheithauer, J. L. Myers

Research output: Contribution to journalArticle

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Abstract

In a 64-year-old woman, a solitary pulmonary nodule developed 30 months after combination chemotherapy and thoracic irradiation had been administered for small-cell carcinoma of the ipsilateral lung. No evidence of extrapulmonary tumor was identified, and the nodule was excised. The well- circumscribed tumor had histologic features of a malignant ependymoma. Immunohistochemical staining showed strong reactivity for glial fibrillary acidic protein; staining for S-100 protein, Leu-7, and vimentin was less intense. Focal reactivity for epithelial membrane antigen also was present. Stains for keratin, synaptophysin, and chromogranin were negative. Electron microscopy showed cohesive cells, the cytoplasm of which contained intermediate filaments. Rare well-formed junctions also were noted. Flow cytometry of formalin-fixed paraffin-embedded tissue demonstrated DNA aneuploidy. Six months after the ependymoma was diagnosed, the patient, who had a history of hypertension, died of an intracerebral hemorrhage.

Original languageEnglish (US)
Pages (from-to)373-378
Number of pages6
JournalMayo Clinic Proceedings
Volume67
Issue number4
StatePublished - 1992
Externally publishedYes

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Ependymoma
Solitary Pulmonary Nodule
Staining and Labeling
Chromogranins
Mucin-1
Lung
Synaptophysin
Intermediate Filaments
S100 Proteins
Glial Fibrillary Acidic Protein
Small Cell Lung Carcinoma
Cerebral Hemorrhage
Aneuploidy
Vimentin
Keratins
Combination Drug Therapy
Paraffin
Formaldehyde
Neoplasms
Electron Microscopy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Crotty, T. B., Hooker, R. P., Swensen, S. J., Scheithauer, B. W., & Myers, J. L. (1992). Primary malignant ependymoma of the lung. Mayo Clinic Proceedings, 67(4), 373-378.

Primary malignant ependymoma of the lung. / Crotty, T. B.; Hooker, R. P.; Swensen, S. J.; Scheithauer, B. W.; Myers, J. L.

In: Mayo Clinic Proceedings, Vol. 67, No. 4, 1992, p. 373-378.

Research output: Contribution to journalArticle

Crotty, TB, Hooker, RP, Swensen, SJ, Scheithauer, BW & Myers, JL 1992, 'Primary malignant ependymoma of the lung', Mayo Clinic Proceedings, vol. 67, no. 4, pp. 373-378.
Crotty TB, Hooker RP, Swensen SJ, Scheithauer BW, Myers JL. Primary malignant ependymoma of the lung. Mayo Clinic Proceedings. 1992;67(4):373-378.
Crotty, T. B. ; Hooker, R. P. ; Swensen, S. J. ; Scheithauer, B. W. ; Myers, J. L. / Primary malignant ependymoma of the lung. In: Mayo Clinic Proceedings. 1992 ; Vol. 67, No. 4. pp. 373-378.
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