Primary lymphoma of the spinal cord

S. E. Schild, R. E. Wharen, D. M. Menke, W. N. Folger, Gerardo Colon-Otero

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Non-Hodgkin's lymphomas arising in the spinal cord are extremely rare. Only eight single case reports have been well confirmed in the literature. Herein we describe a 59-year-old woman with symptoms attributable to a spinal cord lesion. Physical examination revealed neurologic deficits but no evidence of tumor elsewhere. Although several imaging studies were performed, only magnetic resonance imaging with use of gadolinium revealed the exact site and extent of the lesion. Laminectomy and direct examination of the spinal cord disclosed a discolored region at the level of the 11th thoracic vertebra. A biopsy specimen was obtained, and pathologic examination revealed an intermediate grade, mixed cell lymphoma of T-cell origin. Radiotherapy was administered to the lesion and adjacent region of the spinal cord with use of 6-MV photons and an anteroposterior-posteroanterior technique; the total dose was 45 Gy in 23 fractions. No chemotherapy was given. After 3 years of follow-up, the neurologic signs and symptoms were stable, and repeated magnetic resonance imaging with use of gadolinium showed no residual tumor. In addition to the case report, we review the literature on primary lymphomas of the central nervous system and discuss treatment recommendations.

Original languageEnglish (US)
Pages (from-to)256-260
Number of pages5
JournalMayo Clinic Proceedings
Volume70
Issue number3
StatePublished - 1995

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Lymphoma
Spinal Cord
Gadolinium
Neurologic Manifestations
Non-Hodgkin's Lymphoma
Magnetic Resonance Imaging
Thoracic Vertebrae
Laminectomy
Residual Neoplasm
Photons
Physical Examination
Radiotherapy
Central Nervous System
T-Lymphocytes
Biopsy
Drug Therapy
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Schild, S. E., Wharen, R. E., Menke, D. M., Folger, W. N., & Colon-Otero, G. (1995). Primary lymphoma of the spinal cord. Mayo Clinic Proceedings, 70(3), 256-260.

Primary lymphoma of the spinal cord. / Schild, S. E.; Wharen, R. E.; Menke, D. M.; Folger, W. N.; Colon-Otero, Gerardo.

In: Mayo Clinic Proceedings, Vol. 70, No. 3, 1995, p. 256-260.

Research output: Contribution to journalArticle

Schild, SE, Wharen, RE, Menke, DM, Folger, WN & Colon-Otero, G 1995, 'Primary lymphoma of the spinal cord', Mayo Clinic Proceedings, vol. 70, no. 3, pp. 256-260.
Schild SE, Wharen RE, Menke DM, Folger WN, Colon-Otero G. Primary lymphoma of the spinal cord. Mayo Clinic Proceedings. 1995;70(3):256-260.
Schild, S. E. ; Wharen, R. E. ; Menke, D. M. ; Folger, W. N. ; Colon-Otero, Gerardo. / Primary lymphoma of the spinal cord. In: Mayo Clinic Proceedings. 1995 ; Vol. 70, No. 3. pp. 256-260.
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