Primary localized amyloidosis of the urinary bladder: A case series of 31 patients

Oltita Tirzaman, Dietlind L. Wahner-Roedler, Reza S. Malek, Thomas J. Sebo, Chin Yang Li, Robert A. Kyle

Research output: Contribution to journalArticle

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Abstract

Objective: To evaluate the presentation and prognosis of primary localized amyloidosis of the urinary bladder. Patients and Methods: The medical records of 31 patients with primary localized amyloidosis of the urinary bladder were reviewed. Immunohistochemical amyloid typing was performed on bladder biopsy specimens from 27 patients. Results: The median age of the 22 men and 9 women was 55 years. Twenty-four patients (77%) presented with gross hematuria (associated with irritative urinary tract symptoms in 6 patients), and 7 (23%) had only irritative lower urinary tract symptoms. Multiple bladder areas were involved in 20 patients (65%), a single area was involved in 8 (26%), and diffuse involvement was present in 3 (10%). Twenty-four patients had immunoglobulin light chain, and 3 had transthyretin-related amyloid. Local recurrences were common. None of the patients developed systemic amyloidosis. Conclusion: Primary localized amyloidosis of the urinary bladder can be easily confused with a neoplasm. Immunohistochemical amyloid typing is important. Transthyretin-related amyloid of the bladder requires no further work-up. Repeated work-ups for systemic amyloidosis are unnecessary for patients with light chain-related amyloidosis of the urinary bladder. Early eradication with fulguration or laser therapy is indicated. Cystoscopic follow-up is necessary.

Original languageEnglish (US)
Pages (from-to)1264-1268
Number of pages5
JournalMayo Clinic Proceedings
Volume75
Issue number12
StatePublished - 2000

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Urinary Bladder
Amyloid
Amyloidosis
Prealbumin
Immunoglobulin Light Chains
Primary amyloidosis
Lower Urinary Tract Symptoms
Laser Therapy
Hematuria
Urinary Tract
Medical Records
Biopsy
Light
Recurrence
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tirzaman, O., Wahner-Roedler, D. L., Malek, R. S., Sebo, T. J., Li, C. Y., & Kyle, R. A. (2000). Primary localized amyloidosis of the urinary bladder: A case series of 31 patients. Mayo Clinic Proceedings, 75(12), 1264-1268.

Primary localized amyloidosis of the urinary bladder : A case series of 31 patients. / Tirzaman, Oltita; Wahner-Roedler, Dietlind L.; Malek, Reza S.; Sebo, Thomas J.; Li, Chin Yang; Kyle, Robert A.

In: Mayo Clinic Proceedings, Vol. 75, No. 12, 2000, p. 1264-1268.

Research output: Contribution to journalArticle

Tirzaman, O, Wahner-Roedler, DL, Malek, RS, Sebo, TJ, Li, CY & Kyle, RA 2000, 'Primary localized amyloidosis of the urinary bladder: A case series of 31 patients', Mayo Clinic Proceedings, vol. 75, no. 12, pp. 1264-1268.
Tirzaman O, Wahner-Roedler DL, Malek RS, Sebo TJ, Li CY, Kyle RA. Primary localized amyloidosis of the urinary bladder: A case series of 31 patients. Mayo Clinic Proceedings. 2000;75(12):1264-1268.
Tirzaman, Oltita ; Wahner-Roedler, Dietlind L. ; Malek, Reza S. ; Sebo, Thomas J. ; Li, Chin Yang ; Kyle, Robert A. / Primary localized amyloidosis of the urinary bladder : A case series of 31 patients. In: Mayo Clinic Proceedings. 2000 ; Vol. 75, No. 12. pp. 1264-1268.
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