Primary localized amyloidosis of the urinary bladder: A case series of 31 patients

Oltita Tirzaman, Dietlind L. Wahner-Roedler, Reza S. Malek, Thomas J. Sebo, Chin Yang Li, Robert A. Kyle

Research output: Contribution to journalArticlepeer-review

97 Scopus citations

Abstract

Objective: To evaluate the presentation and prognosis of primary localized amyloidosis of the urinary bladder. Patients and Methods: The medical records of 31 patients with primary localized amyloidosis of the urinary bladder were reviewed. Immunohistochemical amyloid typing was performed on bladder biopsy specimens from 27 patients. Results: The median age of the 22 men and 9 women was 55 years. Twenty-four patients (77%) presented with gross hematuria (associated with irritative urinary tract symptoms in 6 patients), and 7 (23%) had only irritative lower urinary tract symptoms. Multiple bladder areas were involved in 20 patients (65%), a single area was involved in 8 (26%), and diffuse involvement was present in 3 (10%). Twenty-four patients had immunoglobulin light chain, and 3 had transthyretin-related amyloid. Local recurrences were common. None of the patients developed systemic amyloidosis. Conclusion: Primary localized amyloidosis of the urinary bladder can be easily confused with a neoplasm. Immunohistochemical amyloid typing is important. Transthyretin-related amyloid of the bladder requires no further work-up. Repeated work-ups for systemic amyloidosis are unnecessary for patients with light chain-related amyloidosis of the urinary bladder. Early eradication with fulguration or laser therapy is indicated. Cystoscopic follow-up is necessary.

Original languageEnglish (US)
Pages (from-to)1264-1268
Number of pages5
JournalMayo Clinic proceedings
Volume75
Issue number12
DOIs
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • Medicine(all)

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