Primary intracerebral malignant lymphoma

A clinicopathological study of 89 patients

F. H. Tomlinson, P. J. Kurtin, Vera Jean Suman, B. W. Scheithauer, J. R. O'Fallon, P. J. Kelly, Clifford R Jr. Jack, Brian Patrick O'Neill

Research output: Contribution to journalArticle

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Abstract

The authors report on a clinicopathological study of 89 surgical patients with histologically proven primary parenchymal brain lymphoma, all diagnosed between January 1975 and December 1990. The cohort included 60 men and 29 women whose median age at diagnosis was 60 years (range 14 to 84 years). The duration of symptoms was less than 8 weeks in 48% of the patients. Symptom groups included focal neurological deficit (73%), neuropsychiatric symptoms (28%), seizures (9%), and increased intracranial pressure (3%). A total of 132 tumors were seen in 89 patients: the most common sites were frontal (32 patients), temporoparietal (31 patients), and basal ganglia (17 patients); multiple lesions were reported in 23 patients. No patient had antecedent of human immunodeficiency virus positivity or acquired immunodeficiency syndrome. A family history of cancer was present in 33% of the patients, three-quarters of whom were first-degree relatives. Histological subtypes (National Cancer Institute Working Formulation) included 64 large cell (72%) and 13 immunoblastic (15%) tumors. Phenotype was determined in 66 patients: 63 were B-cell type and three were T-cell type. Surgical resection was performed in 47% of the cases, with the remainder undergoing biopsy only. All but six patients received radiation therapy. Thirty-one patients received chemotherapy, whereas 46 patients did not; data on the remaining 12 patients were unavailable. The end point of the study was death from any cause. At the time of last contact, 69 of the patients (78%) had died; the median survival time for this study group was 20.9 months. On univariate analysis, prognostic factors significantly associated with survival included age at diagnosis, family history of cancer, and focal neurological deficit. Multivariate analysis revealed four unfavorable prognostic factors: age greater than or equal to 60 years, history of cancer in first-degree relatives, focal deficit, and ependymal contact. After adjustment for these variables, clinical syndrome, size and number of lesions, extent of surgery, histological cell type, radiation dose, and use of chemotherapy were not significantly associated with survival.

Original languageEnglish (US)
Pages (from-to)558-566
Number of pages9
JournalJournal of Neurosurgery
Volume82
Issue number4
StatePublished - 1995

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Lymphoma
Neoplasms
Survival
Drug Therapy
Time and Motion Studies
National Cancer Institute (U.S.)
Intracranial Pressure
Basal Ganglia
Cause of Death
Acquired Immunodeficiency Syndrome
Seizures
B-Lymphocytes
Radiotherapy
Multivariate Analysis
HIV
Radiation
T-Lymphocytes
Phenotype
Biopsy

Keywords

  • brain neoplasm
  • non-Hodgkin's lymphoma
  • primary central nervous system lymphoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Tomlinson, F. H., Kurtin, P. J., Suman, V. J., Scheithauer, B. W., O'Fallon, J. R., Kelly, P. J., ... O'Neill, B. P. (1995). Primary intracerebral malignant lymphoma: A clinicopathological study of 89 patients. Journal of Neurosurgery, 82(4), 558-566.

Primary intracerebral malignant lymphoma : A clinicopathological study of 89 patients. / Tomlinson, F. H.; Kurtin, P. J.; Suman, Vera Jean; Scheithauer, B. W.; O'Fallon, J. R.; Kelly, P. J.; Jack, Clifford R Jr.; O'Neill, Brian Patrick.

In: Journal of Neurosurgery, Vol. 82, No. 4, 1995, p. 558-566.

Research output: Contribution to journalArticle

Tomlinson, FH, Kurtin, PJ, Suman, VJ, Scheithauer, BW, O'Fallon, JR, Kelly, PJ, Jack, CRJ & O'Neill, BP 1995, 'Primary intracerebral malignant lymphoma: A clinicopathological study of 89 patients', Journal of Neurosurgery, vol. 82, no. 4, pp. 558-566.
Tomlinson FH, Kurtin PJ, Suman VJ, Scheithauer BW, O'Fallon JR, Kelly PJ et al. Primary intracerebral malignant lymphoma: A clinicopathological study of 89 patients. Journal of Neurosurgery. 1995;82(4):558-566.
Tomlinson, F. H. ; Kurtin, P. J. ; Suman, Vera Jean ; Scheithauer, B. W. ; O'Fallon, J. R. ; Kelly, P. J. ; Jack, Clifford R Jr. ; O'Neill, Brian Patrick. / Primary intracerebral malignant lymphoma : A clinicopathological study of 89 patients. In: Journal of Neurosurgery. 1995 ; Vol. 82, No. 4. pp. 558-566.
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abstract = "The authors report on a clinicopathological study of 89 surgical patients with histologically proven primary parenchymal brain lymphoma, all diagnosed between January 1975 and December 1990. The cohort included 60 men and 29 women whose median age at diagnosis was 60 years (range 14 to 84 years). The duration of symptoms was less than 8 weeks in 48{\%} of the patients. Symptom groups included focal neurological deficit (73{\%}), neuropsychiatric symptoms (28{\%}), seizures (9{\%}), and increased intracranial pressure (3{\%}). A total of 132 tumors were seen in 89 patients: the most common sites were frontal (32 patients), temporoparietal (31 patients), and basal ganglia (17 patients); multiple lesions were reported in 23 patients. No patient had antecedent of human immunodeficiency virus positivity or acquired immunodeficiency syndrome. A family history of cancer was present in 33{\%} of the patients, three-quarters of whom were first-degree relatives. Histological subtypes (National Cancer Institute Working Formulation) included 64 large cell (72{\%}) and 13 immunoblastic (15{\%}) tumors. Phenotype was determined in 66 patients: 63 were B-cell type and three were T-cell type. Surgical resection was performed in 47{\%} of the cases, with the remainder undergoing biopsy only. All but six patients received radiation therapy. Thirty-one patients received chemotherapy, whereas 46 patients did not; data on the remaining 12 patients were unavailable. The end point of the study was death from any cause. At the time of last contact, 69 of the patients (78{\%}) had died; the median survival time for this study group was 20.9 months. On univariate analysis, prognostic factors significantly associated with survival included age at diagnosis, family history of cancer, and focal neurological deficit. Multivariate analysis revealed four unfavorable prognostic factors: age greater than or equal to 60 years, history of cancer in first-degree relatives, focal deficit, and ependymal contact. After adjustment for these variables, clinical syndrome, size and number of lesions, extent of surgery, histological cell type, radiation dose, and use of chemotherapy were not significantly associated with survival.",
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