Primary hepatic angiosarcoma: Findings at CT and MR imaging

Takashi Koyama, Joel Garland Fletcher, C. Daniel Johnson, Mark S. Kuo, Kenji Notohara, Lawrence J. Burgart

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

PURPOSE: To evaluate and describe cross-sectional imaging findings in patients with pathologically confirmed primary hepatic angiosarcoma. MATERIALS AND METHODS: Findings from imaging examinations in 13 patients with pathologically confirmed primary hepatic angiosarcoma were retrospectively reviewed (computed tomographic [CT] images obtained in 10 patients and magnetic resonance [MR] images obtained in five patients were available for review). Two gastrointestinal radiologists evaluated lesion number, size, attenuation and signal intensity characteristics, and the pattern and degree of contrast material enhancement. Medical records were reviewed for clinical features associated with angiosarcoma. RESULTS: Angiosarcoma appeared as multiple nodules (n = 6), as dominant masses (n = 6), or as a diffusely infiltrating lesion (n = 1). Multiple nodules were hypoattenuating at unenhanced and contrast material-enhanced CT (six of six patients). When dominant masses were encountered at MR imaging, T2-weighted MR imaging demonstrated heterogeneous internal architecture (four of four patients) similar to that of hepatocellular carcinoma. Multiphase contrast-enhanced CT and MR images showed dominant masses to have heterogeneous and progressive enhancement (three of three patients). Clinical features associated with angiosarcoma included splenic metastases (six of 13 patients), thrombocytopenia (seven of 13 patients), disseminated intravascular coagulation (four of 13 patients), and hemolytic anemia (three of 13 patients). CONCLUSION: Primary hepatic angiosarcoma exhibits a spectrum of appearances that reflect its varied pathologic features.

Original languageEnglish (US)
Pages (from-to)667-673
Number of pages7
JournalRadiology
Volume222
Issue number3
StatePublished - 2002

Fingerprint

Hemangiosarcoma
Magnetic Resonance Imaging
Liver
Contrast Media
Magnetic Resonance Spectroscopy
Disseminated Intravascular Coagulation
Hemolytic Anemia
Thrombocytopenia
Medical Records
Hepatocellular Carcinoma
Neoplasm Metastasis

Keywords

  • Liver neoplasms
  • Liver nodules
  • Sarcoma

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Koyama, T., Fletcher, J. G., Johnson, C. D., Kuo, M. S., Notohara, K., & Burgart, L. J. (2002). Primary hepatic angiosarcoma: Findings at CT and MR imaging. Radiology, 222(3), 667-673.

Primary hepatic angiosarcoma : Findings at CT and MR imaging. / Koyama, Takashi; Fletcher, Joel Garland; Johnson, C. Daniel; Kuo, Mark S.; Notohara, Kenji; Burgart, Lawrence J.

In: Radiology, Vol. 222, No. 3, 2002, p. 667-673.

Research output: Contribution to journalArticle

Koyama, T, Fletcher, JG, Johnson, CD, Kuo, MS, Notohara, K & Burgart, LJ 2002, 'Primary hepatic angiosarcoma: Findings at CT and MR imaging', Radiology, vol. 222, no. 3, pp. 667-673.
Koyama T, Fletcher JG, Johnson CD, Kuo MS, Notohara K, Burgart LJ. Primary hepatic angiosarcoma: Findings at CT and MR imaging. Radiology. 2002;222(3):667-673.
Koyama, Takashi ; Fletcher, Joel Garland ; Johnson, C. Daniel ; Kuo, Mark S. ; Notohara, Kenji ; Burgart, Lawrence J. / Primary hepatic angiosarcoma : Findings at CT and MR imaging. In: Radiology. 2002 ; Vol. 222, No. 3. pp. 667-673.
@article{e761455d0cd045d4935f44a0a4b008c2,
title = "Primary hepatic angiosarcoma: Findings at CT and MR imaging",
abstract = "PURPOSE: To evaluate and describe cross-sectional imaging findings in patients with pathologically confirmed primary hepatic angiosarcoma. MATERIALS AND METHODS: Findings from imaging examinations in 13 patients with pathologically confirmed primary hepatic angiosarcoma were retrospectively reviewed (computed tomographic [CT] images obtained in 10 patients and magnetic resonance [MR] images obtained in five patients were available for review). Two gastrointestinal radiologists evaluated lesion number, size, attenuation and signal intensity characteristics, and the pattern and degree of contrast material enhancement. Medical records were reviewed for clinical features associated with angiosarcoma. RESULTS: Angiosarcoma appeared as multiple nodules (n = 6), as dominant masses (n = 6), or as a diffusely infiltrating lesion (n = 1). Multiple nodules were hypoattenuating at unenhanced and contrast material-enhanced CT (six of six patients). When dominant masses were encountered at MR imaging, T2-weighted MR imaging demonstrated heterogeneous internal architecture (four of four patients) similar to that of hepatocellular carcinoma. Multiphase contrast-enhanced CT and MR images showed dominant masses to have heterogeneous and progressive enhancement (three of three patients). Clinical features associated with angiosarcoma included splenic metastases (six of 13 patients), thrombocytopenia (seven of 13 patients), disseminated intravascular coagulation (four of 13 patients), and hemolytic anemia (three of 13 patients). CONCLUSION: Primary hepatic angiosarcoma exhibits a spectrum of appearances that reflect its varied pathologic features.",
keywords = "Liver neoplasms, Liver nodules, Sarcoma",
author = "Takashi Koyama and Fletcher, {Joel Garland} and Johnson, {C. Daniel} and Kuo, {Mark S.} and Kenji Notohara and Burgart, {Lawrence J.}",
year = "2002",
language = "English (US)",
volume = "222",
pages = "667--673",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "3",

}

TY - JOUR

T1 - Primary hepatic angiosarcoma

T2 - Findings at CT and MR imaging

AU - Koyama, Takashi

AU - Fletcher, Joel Garland

AU - Johnson, C. Daniel

AU - Kuo, Mark S.

AU - Notohara, Kenji

AU - Burgart, Lawrence J.

PY - 2002

Y1 - 2002

N2 - PURPOSE: To evaluate and describe cross-sectional imaging findings in patients with pathologically confirmed primary hepatic angiosarcoma. MATERIALS AND METHODS: Findings from imaging examinations in 13 patients with pathologically confirmed primary hepatic angiosarcoma were retrospectively reviewed (computed tomographic [CT] images obtained in 10 patients and magnetic resonance [MR] images obtained in five patients were available for review). Two gastrointestinal radiologists evaluated lesion number, size, attenuation and signal intensity characteristics, and the pattern and degree of contrast material enhancement. Medical records were reviewed for clinical features associated with angiosarcoma. RESULTS: Angiosarcoma appeared as multiple nodules (n = 6), as dominant masses (n = 6), or as a diffusely infiltrating lesion (n = 1). Multiple nodules were hypoattenuating at unenhanced and contrast material-enhanced CT (six of six patients). When dominant masses were encountered at MR imaging, T2-weighted MR imaging demonstrated heterogeneous internal architecture (four of four patients) similar to that of hepatocellular carcinoma. Multiphase contrast-enhanced CT and MR images showed dominant masses to have heterogeneous and progressive enhancement (three of three patients). Clinical features associated with angiosarcoma included splenic metastases (six of 13 patients), thrombocytopenia (seven of 13 patients), disseminated intravascular coagulation (four of 13 patients), and hemolytic anemia (three of 13 patients). CONCLUSION: Primary hepatic angiosarcoma exhibits a spectrum of appearances that reflect its varied pathologic features.

AB - PURPOSE: To evaluate and describe cross-sectional imaging findings in patients with pathologically confirmed primary hepatic angiosarcoma. MATERIALS AND METHODS: Findings from imaging examinations in 13 patients with pathologically confirmed primary hepatic angiosarcoma were retrospectively reviewed (computed tomographic [CT] images obtained in 10 patients and magnetic resonance [MR] images obtained in five patients were available for review). Two gastrointestinal radiologists evaluated lesion number, size, attenuation and signal intensity characteristics, and the pattern and degree of contrast material enhancement. Medical records were reviewed for clinical features associated with angiosarcoma. RESULTS: Angiosarcoma appeared as multiple nodules (n = 6), as dominant masses (n = 6), or as a diffusely infiltrating lesion (n = 1). Multiple nodules were hypoattenuating at unenhanced and contrast material-enhanced CT (six of six patients). When dominant masses were encountered at MR imaging, T2-weighted MR imaging demonstrated heterogeneous internal architecture (four of four patients) similar to that of hepatocellular carcinoma. Multiphase contrast-enhanced CT and MR images showed dominant masses to have heterogeneous and progressive enhancement (three of three patients). Clinical features associated with angiosarcoma included splenic metastases (six of 13 patients), thrombocytopenia (seven of 13 patients), disseminated intravascular coagulation (four of 13 patients), and hemolytic anemia (three of 13 patients). CONCLUSION: Primary hepatic angiosarcoma exhibits a spectrum of appearances that reflect its varied pathologic features.

KW - Liver neoplasms

KW - Liver nodules

KW - Sarcoma

UR - http://www.scopus.com/inward/record.url?scp=0036186935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036186935&partnerID=8YFLogxK

M3 - Article

C2 - 11867783

AN - SCOPUS:0036186935

VL - 222

SP - 667

EP - 673

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 3

ER -