Primary failure of OKT3 antibody for rejection prophylaxis in orthotopic heart transplantation

W. T. Vigneswaran, R. J. Rodeheffer, J. A. Katzmann, H. D. Tazelaar, C. G A McGregor

Research output: Contribution to journalArticle

Abstract

Cytolytic immunosuppression with OKT3 antibody has been shown to be highly effective in reducing the frequency of early allograft rejection in cardiac transplantation. Failure of OKT3 immunosuppression in the absence of anti-OKT3 antibodies is a rare event, having been reported in only 3 patients who manifested predominantly vascular (humoral) rejection during OKT3 therapy. We report the first case of hemodynamically serious cellular rejection, without a demonstrable vascular rejection component, in a cardiac allograft recipient during OKT3 treatment. This case underscores the need to remain vigilant for signs of rejection in cardiac recipients during OKT3 immunosuppression.

Original languageEnglish (US)
Pages (from-to)537-540
Number of pages4
JournalClinical Transplantation
Volume7
Issue number6
StatePublished - 1993

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Keywords

  • Cardiac transplantation
  • Immunosuppression
  • OKT3

ASJC Scopus subject areas

  • Immunology
  • Transplantation

Cite this

Vigneswaran, W. T., Rodeheffer, R. J., Katzmann, J. A., Tazelaar, H. D., & McGregor, C. G. A. (1993). Primary failure of OKT3 antibody for rejection prophylaxis in orthotopic heart transplantation. Clinical Transplantation, 7(6), 537-540.